Education Background
Ph.D. 2008-2010, Major in Medicinal Chemistry,
Department of Medicinal Chemistry,
School of Pharmaceutical Sciences, Shandong University.
M.S. 2005-2008, Major in Medicinal Chemistry,
Department of Medicinal Chemistry,
School of Pharmaceutical Sciences, Shandong University.
B.S. 2001-2005, Major in Pharmaceutical Engineering,
School
of Pharmaceutical Sciences, Shandong University
.
Research Experience
2014.11- As an Associate Professor of in Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, P.R. China.
2012.11-2014.11 As a JSPS Postdoctoral Fellow in Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.
2010.7-2012.11 As a Researcher (Lecturer) in Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, P.R. China.
Honors and Awards:
"National Excellent 100 Doctoral Dissertation (nominee)",
20
12.
Postdoctoral Fellow Allowance from Japan Society for the Promotion of Science (JSPS) (ID No. P12418),
2012-2014
Superiority doctor graduation thesis of Shandong Province,
2011.
The first prize of Shandong high school excellent scientific research achievement in
2010
.
The first prize of Shandong Province Science and Technology Innovation Achievement excellent graduate Award (ranked first) in
2010
.
“President” Scholarship of Shandong University,
200
9. (“President” Scholarship is the supreme award for students in Shandong University).
Postgraduate Scholarship for
Novelty Activities of Shandong University,
200
9.
Postgraduate Superiority Scholarship of Shandong University,
200
6.
Postgraduate Superiority Scholarship of Shandong University,
2007.
Superiority master graduation thesis of Shandong University,
2009.
Superiority master graduation thesis of Shandong Province,
2009.
Excellent thesis third prize honour in “National postgraduate summer school on chemical biology and drug design”, August 4-19,
2009, Nanjing, China.
Award of Merit for excellent thesis in the 2009 National PhD's Academic Conference---“Scientific problems and key technologies in the research of innovating drugs”. October 16-18,
2009, Nanjing, China.
Funded Research Projects (as principal):
1. National Natural Science Foundation of China (NSFC), Contract grant numbers: 81102320; 2012.01-2014.12
2. Research Fund for the Doctoral Program of Higher Education of China, Contract grant number: 20110131120037; 2012.01-2015.12
3. The Science and Technology Development Project of Shandong Province, Contract grant number: 2014GSF118012; 2015.01-2017.12
4. The Special Program of the Postdoctoral Science Foundation of China, Contract grant number: 2012T50584; 2012.10-2013.10
5. The General Program of the Postdoctoral Science Foundation of China, Contract grant number: 20100481282; 2011.01-2012.12
6. Research Project funded by JSPS (Japan Society for the Promotion of Science), Contract grant number: 12F02418; 2012-2013
7. Shangdong Postdoctoral Innovation Science Research Special Program, Contract grant number: 201002023; 2011.1-2013.06
8. Independent Innovation Foundation of Shandong University (IIFSDU), Contract grant number: 2010GN044; 2010.10-2012.12
Representative Papers Publication (2010.01-2015.01)
Zhan P, Chen X, Li D, Fang Z, De Clercq E, Liu X*.Med Res Rev.
2013;33 Suppl 1:E1-E72.
10 most-accessed article
in Med Res Rev (2013).
Zhan P
, Chen X, Li X, Li D, Tian Y, Chen W, Pannecouque C, De Clercq E, Liu X*. Eur J Med Chem.
2011;46(10):5039-45.
Zhan P, Chen W, Li Z, Li X, Chen X, Tian Y, Pannecouque C, Clercq ED, Liu X*. Bioorg Med Chem.
2012;20(23):6795-802.
Wang J,
Zhan P*, Li Z, Liu H, De Clercq E, Pannecouque C, Liu X*. Eur J Med Chem.
2014;76C:531-538.
Li X, Chen W, Tian Y, Liu H,
Zhan P*, De Clercq E, Pannecouque C, Balzarini J, Liu X*. Eur J Med Chem.
2014;80C:112-121.
Zhan P, Li X, Li Z, Chen X, Tian Y, Chen W, Liu X*, Pannecouque C, Clercq ED. Bioorg Med Chem Lett.
2012;22(23):7155-62.
Zhan P, Liu X*. Expert Opin Ther Pat.
2011;21(5):717-96.
(invited article)
Zhan P, Liu X*.
Curr Med Chem.
2013;20(13):1743-58.
(invited article)
Zhan P, Liu X*, De Clercq E. Curr Med Chem.
2010; 17(6):495-503.
Zhan P, Li W, Chen H, Liu X*.Curr Med Chem.
2010, 17(29), 3393-3409.
Zhan P, Liu X*, De Clercq E. Curr Med Chem.
2011, 18(1), 29-46.
Zhan P, Wang L, Liu H, Chen X, Li X, Jiang X, Zhang Q, Liu X*, Pannecouque C, Naesens L, De Clercq E, Liu A, Du G. Arch Pharm Res.
2012, 35(6): 975-86.
Zhan P, Liu X*, Li Z, Fang Z, Pannecouque C, De Clercq E. Chem Biodivers. 2010;7(7):1717-27.
Zhan P, Jiang X, Liu X*. Mini Rev Med Chem.
2010;10(2):162-71.
Zhan P, Li Z, Liu X*. Mini Rev Med Chem.
2010;10(10):966-76.
Zhan P, Li D, Li J, Chen X, Liu X*. Mini-Reviews in Organic Chemistry.
2012, 9(4): 397-410.
Zhan P, Yan R, Liu X*, Pannecouque C, Witvrouw M, De Clercq E, Molina MT, Vega S. Drug Discov Ther.
2011; 5(6):279-285.
Song Y,
Zhan P*, Kang D, Li X, Tian Y, Li Z, Chen X, Chen W, Pannecouque C, De Clercq E, Liu X*. Med. Chem. Commun.,
2013,4, 810-816.
Zhan P*, Song Y, Itoh Y, Suzuki T*, Liu X*. Mol Biosyst.
2014;10(11):2783-99.
Song Y,
Zhan P*, Liu X*. Curr Pharm Des.
2013;19(40):7141-54.
Song Y,
Zhan P*, Liu X*, Zhang Q. Curr Pharm Des.
2013;19(8):1528-48.
Li X,
Zhan P*, Liu H, Li D, Wang L, Chen X, Liu H, Pannecouque C, Balzarini J, Clercq ED, Liu X*. Bioorg Med Chem.
2012, 20(18):5527-36.
Song Y,
Zhan P*, Li X, Rai D, Clercq ED, Liu X*. Curr Med Chem.
2013;20(6):815-32.
Li X,
Zhan P*, Clercq ED, Liu X*.
Curr Med Chem.
2012;19(36):6138-49.
Liu Z, Chen W,
Zhan P*, De Clercq E, Pannecouque C, Liu X*. Eur J Med Chem.
2014;87C:52-62.
Liu T#, Huang B#,
Zhan P*, De Clercq E, Liu X*. Eur J Med Chem.
2014;86C:481-490.
Song Y, Fang Z,
Zhan P*, Liu X*. Curr Med Chem.
2013;21(3):329-55.
Fang Z, Song Y,
Zhan P*, Zhang Q*, Liu X*. Future Med Chem.
2014;6(8):885-901.
Dongwei Kang, Yuning Song,
Peng Zhan*, Qingzhu Zhang, and
Xinyong Liu*. Journal of Chemistry, vol.
2013, Article ID 107302, 9 pages, doi:10.1155/2013/107302
Cao L, Song W, De Clercq E,
Zhan P*, Liu X*. Curr Med Chem.
2014;21(17):1956-67.
Kang D, Song Y,
Chen W,
Zhan P*
,
Liu X*. Mol Biosyst.
2014;10(8):1998-2022.
Song Y, Chen W, Kang D,
Zhan P*, Liu X*. Comb Chem High Throughput Screen.
2014;17(6):536-53.
Yu'ning Song, Hao Xu, Wenmin Chen,
Peng Zhan* and Xinyong Liu*.
MedChemComm,
2015, 6, 61-74.
Li X, Zhang L, Tian Y, Song Y*,
Zhan P*, Liu X*. Expert Opin Ther Pat.
2014;24(11):1199-227.
Wang L, Tian Y, Chen W, Liu H,
Zhan P*, De Clercq E, Pannecouque C, Balzarini J, Liu X*. Eur J Med Chem.
2014;85C:293-303.
Song Y, Lin X, Kang D, Li X,
Zhan P*, Liu X*, Zhang Q*. Eur J Med Chem.
2014;82C:293-307.
Li X, Lu X, Chen W, Liu H,
Zhan P*, Pannecouque C, Balzarini J, De Clercq E, Liu X*. Bioorg Med Chem.
2014;22(19):5290-7.
Tian Y, Du D, Rai D, Wang L, Liu H,
Zhan P*, De Clercq E, Pannecouque C, Liu X*. Bioorg Med Chem.
2014;22(7):2052-9.
Huang B, Li C, Chen W, Liu T, Yu M, Fu L, Sun Y, Liu H, De Clercq E, Pannecouque C, Balzarini J,
Zhan P*, Liu X*. Eur J Med Chem.
2015;92C:754-765.
Fang Z#, Kang D#, Zhang L, Huang B, Liu H, Pannecouque C, De Clercq E,
Zhan P*, Liu X*. Chem Biol Drug Des.
2015 Jan 27. doi: 10.1111/cbdd.12524. [Epub ahead of print]
41 Kang D#, Fang Z#, Huang B, Zhang L, Liu H, Pannecouque C, Naesens L, De Clercq E,
Zhan P*, Liu X*. Chem Biol Drug Des.
2015 Jan 20. doi: 10.1111/cbdd.12520. [Epub ahead of print]
Na Liu, Fabao Zhao, Haiyong Jia, Diwakar Rai,
Peng Zhan,* Xuemei Jiang* and Xinyong Liu*. Med. Chem. Commun., (
2015), DOI: 10.1039/c4md00521j.
Tao Liu, Boshi Huang, Ye Tian, Xin Liang, Hong Liu, Huiqing Liu,
Peng Zhan,* Erik De Clercq, Christophe Pannecouque and Xinyong Liu*. Chemical Biology & Drug Design.
2014, Accepted Article, doi: 10.1111/cbdd.12468.
Monograph
Anti-AIDS Drug Research [M], Chief editor: Xinyong Liu.
People Health Publishing House. Bei Jing. December,
2006.
Selected Patents
1.
Zhan, Peng; Liu, Xinyong; Song, Yuning; Kang, Dongwei; Zhang, Qingzhu. Preparation of imidazole derivatives as antitumor drugs. Faming Zhuanli Shenqing (2014), CN 103626769 A 20140312.
2. Liu, Xinyong;
Zhan, Peng; Li, Xiao; Chen, Xuwang. Preparation of heterocyclic compounds as anti-HIV agents. Faming Zhuanli Shenqing (2011), CN 102276535 A 20111214.
3. Liu, Xinyong;
Zhan, Peng; Fang, Zengjun; Li, Zhenyu. Preparation of heterocycles useful for preventing and treating HIV and influenza virus infection. Faming Zhuanli Shenqing (2010), CN 101914074 A 20101215.
4. Liu, Xinyong;
Zhan, Peng; Fang, Zengjun. Method for preparation of 2-(2-substituted aryl-2H-1,2,4-triazole-3-mercapto)acetamide derivatives, and the preparation and medical application as anti-AIDS agent. Faming Zhuanli Shenqing (2010), CN 101899013 A 20101201.
5. Liu, Xinyong;
Zhan, Peng; Fang, Zengjun. A process for preparing 2-(1,2,3-thiadiazol-5-ylthio)-acetamide derivatives. Faming Zhuanli Shenqing (2009), CN 101585819 A 20091125.
6. Liu, Xinyong; Zhan,
Peng; Fang, Zengjun. Preparation of 1,2,3-selenadiazole derivatives as HIV inhibitors. Faming Zhuanli Shenqing (2009), CN 101585820 A 20091125.
7. Liu, Xinyong;
Zhan, Peng. Preparation of 1-aryl-2-mercaptoimidazole derivatives as HIV-1 inhibitors. Faming Zhuanli Shenqing (2009), CN 101362722 A 20090211.
8. Liu, Xinyong;
Zhan, Peng. Preparation of 2-[(4-phenyl-1,2,3-thiadiazol-5-yl)thio]-N-phenyl- acetamide derivatives as anti-HIV agents. From Faming Zhuanli Shenqing (2009), CN 101362737 A 20090211.
9. Liu, Xinyong; Liang, Xin;
Zhan, Peng. Imidazopyrazine derivatives as antiviral agents and their preparation, pharmaceutical compositions and use in the treatment of HIV infection. Faming Zhuanli Shenqing (2014), CN 104016990 A 20140903.
10. Liu, Xinyong; Liu, Tao;
Zhan, Peng. 2H-1,2,6-Thiadiazin-3(6H)-one-1,1-dioxide derivatives as antiviral agents and their preparation, pharmaceutical compositions and use in the treatment of HIV-1 infection. Faming Zhuanli Shenqing (2014), CN 104016977 A 20140903.
11. Liu, Xinyong; Li, Xiao;
Zhan, Peng. Preparation of pyrimidine mercapto-acetamides derivatives. Faming Zhuanli Shenqing (2014), CN 104016927 A 20140903.
12. Liu, Xinyong; Tian, Ye;
Zhan,
Peng. Substituted pyrazolo[1,5-a]pyrimidine derivative, its preparation method and application in preparation of drug for treatment and prevention of human immunodeficiency virus (HIV) infection. Faming Zhuanli Shenqing (2014), CN 103570728 A 20140212.
13. Liu, Xinyong; Li, Xiao;
Zhan,
Peng. m-Diarene-pyrimidine derivatives as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of HIV infection. Faming Zhuanli Shenqing (2014), CN 103483272 A 20140101.
14. Liu, Xinyong; Liu, Hong;
Zhan,
Peng. Preparation of substituted thiadiazine triketone derivatives for preventing and treating AIDS. Faming Zhuanli Shenqing (2013), CN 103450113 A 20131218.
15. Liu, Xinyong; Wang, Liu;
Zhan,
Peng. Triazolopyrimidines as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of AIDS. Faming Zhuanli Shenqing (2013), CN 103360398 A 20131023,
16. Liu, Xinyong; Jiang, Xin;
Zhan,
Peng. Preparation of aryl-heteroxy acethydrazide derivatives as anti-influenza virus agents. Faming Zhuanli Shenqing (2013), CN 103360315 A 20131023,
17. Liu, Xinyong; Li, Wenjun;
Zhan,
Peng. Method for preparation of (2-(2-oxy-4-thio pyrimidine)ethoxy)methyl phosphonate ester derivative and their application for preparation of anti-HBV drugs. Faming Zhuanli Shenqing (2012), CN 102816184 A 20121212.
18. Liu, Xinyong; Li, Wenjun;
Zhan,
Peng; Liu, Tao. (2-(3-Methylthio-1,2,4-thiadiazine)ethoxy) methyl phosphonate derivative, its preparation and application. Faming Zhuanli Shenqing (2012), CN 102796138 A 20121128.
19. Liu, Xinyong; Tian, Ye;
Zhan,
Peng. Preparation of thiadiazine derivatives as anti-HIV agents. Faming Zhuanli Shenqing (2012), CN 102775371 A 20121114.
20. Liu, Xinyong; Li, Dongyue;
Zhan, Peng. Pyridazine derivatives as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of AIDs. Faming Zhuanli Shenqing (2012), CN 102731410 A 20121017.
21. Liu, Xinyong; Jiang, Xiaofei;
Zhan, Peng. Preparation of 1,2,3-thiadiazole derivatives for treatment of HIV infection. Faming Zhuanli Shenqing (2012), CN 102659714 A 20120912.
22. Liu, Xinyong; Zhan, Peng; Li, Xiao. Preparation of six-membered heteroaryl fused imidazole thioacetamide derivatives as anti-HIV agents. From Faming Zhuanli Shenqing (2012), CN 102516244 A 20120627.
23. Liu, Xinyong; Chen, Wenmin;
Zhan, Peng. N2,N4-Bis-substituted-2H,4H-pyrrolo[1,2-b][1,2,4,6] thiotriazine-1,1,3-trione derivatives useful in the treatment of AIDS and their preparation. Faming Zhuanli Shenqing (2012), CN 102321102 A 20120118.
24. Liu, Xinyong; Chen, Xuwang;
Zhan, Peng. N-1-substituted piperidine-4-arylamine derivative useful in the treatment of HIV infection and its preparation. From Faming Zhuanli Shenqing (2011), CN 102285969 A 20111221.
25. Liu, Xinyong; Zhang, Jing;
Zhan, Peng. 2-Aryl methylthio-6-(tetrahydroquinolin-1-ylmethyl)- 4-pyrimidone derivatives useful in the treatment of HIV-1 and their preparation. Faming Zhuanli Shenqing (2011), CN 102285967 A 20111221.
26. Liu, Xinyong; Li, Zhenyu;
Zhan, Peng. Preparation of benzoxazole derivatives as inhibitors of influenza virus. Faming Zhuanli Shenqing (2011), CN 102070549 A 20110525.
