Dongmei Ren, Ph.D, Professor
ADDRESS:
School of Pharmaceutical Sciences
Shandong University
No.44, Wenhuaxi Road, Jinan, 250012
P.R.China
Tel: 0086-531-88382012
E-mail: rendom@sdu.edu.cn
EDUCATION:
1988--1992: Shandong Medical University , Bachelor
1992--1995: Shandong Traditional Chinese Medicine University , Master
2003--2007: Shandong University, Ph. D
PROFESSIOAN EXPERIENCE:
2010-present: Shandong University, Professor
2015-2016: Center for Drug Evaluation, China Food and Drug Administration
2009-2010: University of Arizona, Research associate
2004-2010: Shandong University, Associate professor
2005: Center for Drug Evaluation, China Food and Drug Administration
1997-2004: Shandong University, Lecturer
1995-1997: Shandong Medical University, Teaching assistant
RESEARCH INTERESTS:
1. Isolation and identification of bioactive natural compounds targeting Nrf2-Keap1 pathway
2. Bioactivity evaluation of Nrf2 activators for cancer chemoprevention
3. Develpoment of novel traditional chinese medicine originated from herbs
RESEARCH FOUNDING:
1. Investigation of quassinoids targeting Nrf2 from Brucea javanica, National Natural Science Foundation, No：81173528,￥580000, PI.
2. Flavonoidal alkaloids from Dracocephalum rupestre, National Natural Science Foundation, No. 30672611, ￥280000, PI.
3. Nrf2 activators from Dracocephalum plants, National Natural Science Foundation No. 30973622, ￥320000, PI.
4. Total flavonoids from Dracocephalum moldavica，Shandong Key Technologies R & D Program, No. 2006GG2202058，PI，￥100000
5. Flavonoidal alkaloids from Dracocephalum plants, Foundation for Excellent Young Scientists in Shandong Province，No. 2008BS02015，PI，￥60000
7. Flavonoidal alkaloids from Dracocephalum plants，China Postdoctoral Science Foundation，No. 20080441137，PI, ￥30000 6. Phytochemicals targeting ARE-Nrf2-Keep1 pathway，Independent Innovation Foundation of Shandong University, No. 2012TS203, ￥100000, PI,
RECENT PUBLICATION:
1. Zhao LJ#, Wen Q#, Yang GT, Huang ZQ, Shen T, Li HZ, Ren DM*. (2016) Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway. Phytomedicine. 23(2): 114-122.
2. Li HZ, Hou Z, Li C, Zhang Y, Shen T, Hu QW, Ren DM *. (2015) Three pairs of diastereoisomeric flavanone glycosides from Viscum articulatum. Fitoterapia. 102:156-162.
3. Yang S, Shen T, Zhao LJ, Li C, Zhang Y, Lou HX, Ren DM*. (2014) Chemical constituents of Lobelia chinensis. Fitoterapia. 93, 168-174.
4. Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondark G, Ren DM*, Zhang D*. (2014) Plant extracts of the family Lauraceae: A potential resource for chemopreventive agents that activate the Nrf2/ARE pathway. Planta Med. 80 (5), 426-434
5. Yang S, Li C, Wang SQ, Zhao LJ, Hou Z, Lou HX, Ren DM*. (2013) Chiral separation of two diastereomeric pairs of enantiomers of novel alkaloid-lignan hybrids from Lobelia chinensis and determination of the tentative absolute configuration. J Chromatogr A. 1311, 134-139.
6. Yang S, Wang LM, Guo XJ, Lou HX and Ren DM*. (2013) A new flavonoid glycoside and other constituents from Dracocephalum moldavica. Nat. Prod. Res. 27(3), 201-207
7. Jing X§, Ren DM§ (co-first author), Wei XB, Shi HY, Zhang XM, Perez R.G., Lou HY*,
Lou HX. (2013) Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. Toxicol. Appl. Pharmacol. 273(3), 672-679.
8. Wang LM, Wang SQ, Yang S, Guo XJ, Lou HX and Ren DM*. (2012) Phenolic alkaloids from the aerial parts of Dracocephalum heterophyllum. Phytochemistry. 82, 166-171.
9. Hu QW, Zhang DD, Wang LM, Lou HX and Ren DM*. (2012) Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem. Toxicol. 50, 1927-1932.
10. Ren DM, Villeneuve NF, Jiang T, Wu TD, Lau A, Toppin AH and Zhang DD*. (2011) Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A 108 (4), 1433 – 8.
