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  • Fengshan WANG
  •  Curriculum Vitae

    Fengshan WANG, Ph.D, Professor

    PERSONAL   DATA:

    Born: January 7, 1961

    Citizenship: China

    Vice Director, National   Glycoengineering Research Center, Shandong University

    Director, Institute of   Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences,   Shandong University

    Executive Director, Institute   of Regulatory Science for Medicall Products, Shandong University

    ADDRESS:

    Institute of Biochemical and Biotechnological Drug

    School of Pharmaceutical Sciences, Cheeloo College of Medicine

    Shandong University

    No.44, Wenhuaxi Road, Jinan, 250012

    P.R.China

    Tel: 0086-531-88382658

    Fax: 0086-531-88382548

    E-mail: fswang@sdu.edu.cn

    EDUCATION:

    1998--2001: East China University of Science and Technology, Shanghai, Ph.D. in Biochemical Engineering.

    1983--1986: Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, M.S. in Biopharmacy.

    1978--1982: Department of Pharmacy, Shandong Medical College, Jinan, Shandong, B.S. in Pharmacy.

    PROFESSIONAL EXPERIENCE:

    2020-presentExecutive Director, Institute of Regulatory Science for Medicall Products, Shandong University

    2015-2020: Vice Dean, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

    2007-2016: Dean, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.

    2007-present: Vice Director, National Glycoengineering Research Center, Shandong University, Jinan, Shandong, China.

    1998- present: Director, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Science, Shandong University, Jinan, Shandong, China.

    1994-1998:    Associate Professor, Department of Biopharmacy, Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, China.

    1995–1996:   Visiting Scholar, Department of Chemistry, Imperial College of Science Technology and Medicine, London, England.

    1988-1994:    Lecturer, Department of Biopharmacy, Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, China.

    1986-1994:    Teaching Assistant, Department of Biopharmacy, Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, China.

    RESEARCH INTERESTS:

    Biochemical and biotechnological drugs; gene cloning and expression; chemical and biotechnological modification of proteins and enzymes; polysaccharides.

    SCIENTIFIC, HONARARY AND PROFESSIONAL SOCIETIES:

    2020-presentSociety of Glyco-Drugs, China Biochemical Pharmaceutical Industry Association.

    2007-present: Associate Chairman of Specialty Committee of Biochemical and Biotechnological Pharmaceuticals, Chinese Pharmaceutical Association.

    2010-present: Honorary Chairman of Industrial Branch of Chinese Society of Biochemistry & Molecular Biology.

    2002-present: Chairman of Expert Committee, China Biochemical Pharmaceutical Industry Association.

    SELECTED PUBLICATION:

    1. Fei Liu, Jinhua Zhang, Linjun Zhang, Mengqi Diao, Peixue Ling*, Fengshan Wang*. Correlation between the synthesis of pullulan and melanin in Aureobasidium pullulans. International Journal of Biological Macromolecules, 2021, 177: 252–260.

    2. Qingyue Liu, Yi Tan, Tingyu Qu, Jianhui Zhang, Xuexia Duan, Hongpeng Xu, Yue Mu, Heran Ma*, Fengshan Wang*. Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro. Life Sciences, 2020, 254: 117772.

    3. Dake Hao, Yahan Fan, Wenwu Xiao, Ruiwu Liu, Christopher Pivetti, Tanaya Walimbe, Fuzheng Guo, Xinke Zhang, Diana L Farmer, Fengshan Wang, Alyssa Panitch, Kit S Lam, Aijun Wang*. Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells. Acta Biomaterialia, 2020, 108: 178-193.

    4. Lu Lu, Hongyuan Chen, Longkun Wang, Lin Zhao, Yanna Cheng, Aijun Wang, Fengshan Wang*, Xinke Zhang*. A Dual Receptor Targeting- and BBB PenetratingPeptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma. International Journal of Nanomedicine, 2020, 15: 8875–8892.

    5. Congcong Chen, Shuaishuai Wang, Madhusudhan Reddy Gadi, He Zhu, Fei Liu, Chang-Cheng Liu*, Lei Li*, Fengshan Wang*, Peixue Ling*, Hongzhi Cao *. Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives. Chem. Commun., 2020, 56: 7549-7552. 

    6. Yiming Jin, Yue Mu, Shuhan Zhang, Pingli Li*, Fengshan Wang*. Preparation and evaluation of the adjuvant effect of curdlan sulfate in improving the efficacy of dendritic cell-based vaccine for antitumor immunotherapy. International Journal of Biological Macromolecules, 2020, 146: 273-284.

    7. Shu Zhang, Honglei Jiang, Shengshi Huang, Pingli Li, Fengshan Wang*. Curdlan sulfate/O-linked quaternized chitosan nanoparticles acting as potential adjuvants promote multiple arms of immune responses. Carbohydrate Polymers, 2019, 213: 100-111.

    8. L. X. Zang, R. R. Du, H. C. Zang, F. S. Wang*, J. Z. Sheng*. Production of Arabidopsis thaliana UDP-Sugar Pyrophosphorylase by Pichia pastoris and Its Application in Efficient UDP-Glucose and UDP-Glucuronic Acid Synthesis. Applied Biochemistry and Microbiology, 2019, 55(6): 631–638.

    9. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao, Fengshan Wang, Hongzhi Cao*. Reprogramming the enzymatic assembly line for site-specific fucosylation. Nature Catalys, 2019, 2: 514-522.

    10. Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang*, Fengshan Wang*. The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems. Asian Journal of Pharmaceutical Sciences, 2019, 14: 595–608.

    11. Wenjie Jiang, Yanna Cheng, Na Zhao, Lian Li, Yikang Shi, Aizhen Zong, Fengshan Wang*. Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells. International Journal of Biological Macromolecules, 2018, 107: 349–362.

    12. Yi-Jun Li, Feng-Xin Yin, Xin-Ke Zhang, Jie Yu, Shuang Zheng, Xin-Lei Song, Feng-Shan Wang, Ju-Zheng Sheng*. Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862 (3): 547-556.

    13. Shu Zhang, Shengshi Huang, Lu Lu, Xinlei Song, Pingli Li, Fengshan Wang*. Curdlan sulfate–O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination. International Journal of Nanomedicine, 2018, 13: 2377-2394.

    14. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan, Ajit Varki, Fengshan Wang*, Hongzhi Cao*. Chemoenzymatic Assembly of mammalian O-mannose glycans. Angew. Chem. Int. Ed. 2018, 57, 9003-9007.

    15. Yiming Jin, Pingli Li, Fengshan Wang*.b-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties. Vaccine, 2018, 36: 5235-5244.

    16. Qixin Chen, Chengzhi Jin, Xintian Shao, Ruilin Guan, Zhiqi Tian, Chenran Wang, Fei Liu,Peixue Ling, Jun-Lin Guan, Liangnian Ji, Fengshan Wang*, Hui Chao*, Jiajie Diao*. Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore. Small, 2018, 14: 1802166.

    17. Xintian Shao, Qixin Chen, Xixi Dou, Lei Chen, Jixu Wu, Wei Zhang, Huarong Shao, Peixue Ling*, Fei Liu*, Fengshan Wang*. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway. Carbohydrate Polymers, 2018, 198: 354–363.

    18. Fuyan Liu,  Xiaofeng Zhang, Yuqiu Li, Hui Gao, Peixue Ling*, Xiaoyan Li, Qixin Chen, Aibin Ma, Huarong Shao, Mei Li, Fengshan Wang*. Simultaneous Screening and Determination of Eight Tetracycline Antibiotics Illegally Adulterated in Herbal Preparations Using HPLC-DAD Combined with LC-MS-MS. Chromatographia, 2018, 81 (36):303-314.

    19. Qixin Chen, Xintian Shao, Peixue Ling*, Fei Liu, Huarong Shao, Aibin Ma, Jixu Wu, Wei Zhang, Fuyan Liu, Guanying Han*, Fengshan Wang*. Low molecular weight xanthan gum suppresses oxidative stress-induced apoptosis in rabbit chondrocytes. Carbohydrate Polymers, 2017, 169:  255–263.

    20. Feng-Xin Yin, Feng-Shan Wang*, Ju-Zheng Sheng*. Uncovering the Catalytic Direction of Chondroitin AC Exolyase. FROM THE REDUCING END TOWARDS THE NON-REDUCING END*. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291(9): 4399–4406.

    21. Yan Li, Lian Li, Zhiwei Li, Juzheng Sheng, Xinke Zhang, Danyang Feng, Xu Zhang, Fengxin Yin, Aijun Wang, Fengshan Wang*. Tat PTD- Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops. Biochimica et Biophysica Acta-General Subject, 2016, 1860: 21372147.

    22. Yuliang Xiao, Pingli Li, Yanna Cheng, Qian Zhang, FengshanWang*. Effect of a-linolenic acid-modified low molecular weight chondroitin sulfate on atherosclerosis in apoE-deficient mice. Biochimica et Biophysica Acta-General Subject, 2016, 1860: 2589–2597.

    23. Xinlei Song, Shu Zhang, Yanna Cheng, Ting Zhao, Qianqian Lian, Lu Lu, Fengshan Wang*. Experimental Study on the Efficacy of Site-Specific PEGylated Human Serum Albumins in Resuscitation from Hemorrhagic Shock. Crit Care Med, 2016, 44(11): e1090-e1096.

    24. Yan Zhang, Caicai Meng, Lan Jin, Xi Chen, Fengshan Wang*, Hongzhi Cao*. Chemoenzymatic synthesis of a-dystroglycan core M1 O-mannose glycans†. Chem. Commun., 2015, 51: 11654-11657.

    25. Pingli Li, Xinke Zhang, Yanna Cheng, Juan Li, Yuliang Xiao, Qian Zhang,Aizhen Zong, Chuanqing Zhong, Fengshan Wang*. Preparation and in vitro immunomodulatory effect of curdlan sulfate. Carbohydrate Polymers, 2014, 102: 852– 861.

    26. Xin Meng, Wenlong Yao, Jiansong Cheng, Xu Zhang, Lan Jin, Hai Yu, Xi Chen, Fengshan Wang*, Hongzhi Cao*. Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes. J. Am. Chem. Soc., 2014, 136, 5205−5208.

    27. Jingzong Qi, Qingli Wang, Zhenhang Yu, Xin Chen and Fengshan Wang*.  Innovative drug R&D in China. Nature Reviews Drug Discovery, 2011, 10(5): 333-334.   

     

    * Correspondence author.

     


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