导师介绍


李孝训 教授
作者:  来源:  发布时间:2018年02月02日 14:16  浏览次数:

 

一、基本情况

李孝训1984年生,山东青岛人。博士,山东大学齐鲁青年学者特聘教授,博士生导师。于201412月毕业于美国威斯康星大学麦迪逊分校并取得博士学位,师从Weiping Tang教授;之后在美国斯坦福大学从事博士后研究,师从著名有机化学大师Barry M. Trost院士;于201712月起在山东大学药学院从事教学科研工作。迄今为止,已在J. Am. Chem. Soc.Angew. Chem. Int. Ed.Chem. Sci. 等国际著名刊物上发表论文二十余篇,他引500余次,H因子12

通讯方式

    地址:山东省济南市文化西路44号山东大学药学院药物化学研究所,邮编:250012

        TEL: +86-531-88382006

        Email: xli@sdu.edu.cn

二、研究领域

1. 基于靶点结构的药物活性小分子的设计、合成及生物活性研究;

2. 具有重要生理活性的复杂天然产物的全合成及构效关系研究。

三、学习及工作经历

2003.9 – 2007.7 中国天津大学药学专业,获理学学士学位;

2007.9 – 2009.7 中国天津大学药物化学专业,获理学硕士学位;

2009.92014.12 美国威斯康星大学麦迪逊分校(University of Wisconsin-Madison) 药学专业获博士学位

2015.3 – 2017.6美国斯坦福大学(Stanford University)化学系进行博士后研究工作

2017.12- 至今 山东大学齐鲁青年学者特聘教授,博士生导师。

四、获得奖励

国家优秀自费留学生奖学金(2014年)

山东大学齐鲁青年学者2017年)

五、代表性文章

1. Barry M. Trost*, Xiaoxun Li. “Palladium Catalyzed Asymmetric Allylic Alkylations via C-H Activation of N-allyl Imines and Glycinates” Chem. Sci. 2017, 8, 6815-6821.

2. Xiaoxun Li, Hui Li, Wangze Song, Po-Sen Tseng, Lingyan Liu, Ilia A. Guzei, Weiping Tang* “Divergent Reactivity of Rhodium (I) Carbenes Derived from Indole Annulations” Angew. Chem. Int. Ed. 2015, 54, 12905-12908.

3. Xiaoxun Li, Wangze Song, and Weiping Tang* “Rhodium-catalyzed Tandem Annulation and [5+1] Cycloaddition: 3-Hydroxy -1,4-enyne as the 5-Carbon component” J. Am. Chem. Soc., 2013, 135, 16797-16800.

4. Xiaoxun Li, Min Zhang, Dongxu Shu, Patrick J. Robichaux, Suyu Huang, and Weiping Tang* “Rhodium-catalyzed Ring Expansion of Cyclopropanes to Seven-membered Rings by 1,5-C-C Bond Migration” Angew. Chem. Int. Ed., 2011, 50, 10421-10424.

5. Xiaoxun Li, Haibo Xie, Xiaoning Fu, Jitian Liu, Haoyuan Wang, Baomin Xi, Xiufang Xu, Peng Liu, Weiping Tang* “Rhodium(I)-catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles” Chem. Eur. J. 2016, 22, 10410-10414.

6. Xiaoxun Li, Wangze Song, Xiaona Ke, Xiufang Xu, Peng Liu, K. N. Houk, Xian-liang Zhao, Weiping Tang* “Rhodium-catalyzed Intramolecular [5+2] Cycloaddition of Inverted 3-Acyloxy-1,4-enyne and Alkyne: Experimental and Theoretical Studies” Chem. Eur. J. 2016, 22,7079 –7083.

7. Xiaoxun Li, Suyu Huang, Casi M. Schienebeck, Dongxu Shu, and Weiping Tang* “Rhodium-Catalyzed Carbonylation of 3-Acyloxy-1,4-enynes for the Synthesis of Cyclopentenones” Org. Lett., 2012, 14, 1584-1587.

8.Xiaoxun Li, Yunfei DuHYPERLINK "http://pubs.acs.org/doi/abs/10.1021/ol9006663?prevSearch=%255BContrib%253A%2Bxiaoxun%2Bli%255D&searchHistoryKey=" \l "cor1"*, Zhidan Liang , Xiangke Li , Yan Pan and Kang ZhaoHYPERLINK "http://pubs.acs.org/doi/abs/10.1021/ol9006663?prevSearch=%255BContrib%253A%2Bxiaoxun%2Bli%255D&searchHistoryKey=" \l "cor1"*“Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions” Org. Lett., 2009, 11, 2643-2646.

9. Xing-zhong Shu, Xiaoxun Li, Dongxu Shu, Suyu Huang, Casi M. Schienebeck, Xin Zhou,Patrick J. Robichaux, and Weiping Tang*Rhodium-catalyzed Intra- and Intermolecular [5+2] Cycloaddition of 3-Acyloxy-1,4-enyne and Alkyne with Concomitant 1,2-Acyloxy Migration” J. Am. Chem. Soc., 2012, 134, 5211-5221.

10. Dongxu Shu, Xiaoxun Li, Min Zhang, Patrick J. Robichaux, and Weiping Tang* “Synthesis of Highly Functionalized Cyclohexenone Rings: Rhodium-Catalyzed 1,3-Acyloxy Migration and Subsequent [5+1] Cycloaddition” Angew. Chem. Int. Ed. 2011, 50, 1346-1349.

 

六、参编著作

Xiaoxun Li, Weiping Tang. Metal-catalyzed [5+1], [5+2] and [5+2+1] cycloadditions. An invited chapter in Science of Synthesis: Metal-Catalyzed Cyclization Reactions. Shengming Ma, Shuanhu Gao. 2016, Thieme, ISBN: 9783131998118.

七、 获得专利

1. Weiping Tang, Xiaoxun Li, Dongxu Shu, Gabrielle N. Winston-Mcpherson. “Synthesis of Diindoleylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them” 2016, US20160039754 A1

2. Weiping Tang, Xiaoxun Li. “Synthesis of cyclopropylindoles and cyclohepta[b]indoles, pharmaceutical compositions containing them, and methods of using them” 2016, WO/2016/090094A1

 

 

 

 
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