School of Pharmaceutical Sciences Shandong University, Jinan 250012, China
Tel/Fax: 86-531-88382490
Email: qxj@sdu.edu.cn
Present Position:
Professor of Pharmacology
Head of Pharmacology
Education Background:
2005.09-2007.12: Ph D, School of Pharmaceutical Sciences, Shandong University
1986.09-1989.07: M. Sci., Shandong Academy of Medical Sciences
1978.10-1983.07: B. MD, Qingdao Medical College
Professional Experience:
2004.3-Present: Professor, School of Pharmaceutical Sciences, Shandong University
2001.12-2004.02: Visiting scholar in Oncology Research Center, Prince of Wales Hospital, New South Wales University
1998.12-2001.11: associate Professor, Shandong Academy of Medical Sciences
1989.08-1998.11: Assistant Professor, Shandong Academy of Medical Sciences
1983.07-1989.08: Assistant research, Shandong Academy of Medical Sciences
Teaching Courses:
Pharmacology, Molecular Pharmacology, Drug Screening Experiment
Research Interests:
(1) Cancer Research
(2) Anticancer drug and Mechanisms
(3) Animal Models for Cancer
Research Grant Support:
Currently Active:
1. The research of signal pathways on Apc-related intestinal adenoma and
colon cancer. The National Natural Science Foundation of China (Grant No. 91229113)
2. Des-gamma-carboxy prothrombin stimulation the growth of human hepatocellular carcinoma cells. The National Natural Science Foundation of China (Grant No. 81173090)
3. Des-gamma-carboxy prothrombin stimulation the growth of human hepatocellular carcinoma cells. The Research Fund for the Doctoral Program of Higher Education.
4. Des-gamma-carboxy prothrombin stimulation the growth of human hepatocellular carcinoma cells. Shandong Provincial Natural Science Foundation.
Recent Publications:
Subo Wang, Yanna Cheng, Fengshan Wang, Lirui Sun, Chunhui Liu, Guanjun Chen, Yuhua Li, S.G. Ward, Xianjun Qu：Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2 Biomedicine & Pharmacotherapy 2008; v62: 297-302.
Li-rui Sun, Xun Li, Yan-na Cheng, Hong-yu Yuan, Ming-hui Chen, Wei Tang, Stephen Geoffrey Ward, Xian-jun Qu. Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells Biomedicine & Pharmacotherapy 2009; 63: 202-208.
Chen MH, Cui SX, Cheng YN, Sun LR, Li QB, Xu WF, Ward SG, Tang W, Qu XJ. Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity. Anticancer Drugs. 2008; 19:957-965.
Meng Ma, Xian-Jun Qu, Guo-Ying Mu, Ming-Hui Chen, Yan-Na Cheng, Norihiro Kokudo, Wei Tang, Shu- Xiang Cui. Vitamin K2 inhibits the growth of hepatocellular carcinoma via decrease of des-gamma-carboxy prothrombin. Chemotherapy, 2009; 55:28-35.
Fu-Jun Gao, Shu-Xiang Cui, Ming-Hui Chen, Yan-Na Cheng, Li-Rui Sun, S. G Ward, Norihiro Kokudo, Wei Tang, Xian-Jun Qu: Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells. Life Sciences 2008, 83; 815-820.
Wang SB, Cheng YN, Cui SX, Zhong JL, Ward SG, Sun LR, Chen MH, Kokudo N, Tang W, Qu XJ. Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration. Clin Exp Metastasis. 2009; 26(5):469-77.
Qu XJ, Xia X, Wang YS, Song MJ, Liu LL, Xie YY, Cheng YN, Liu XJ, Qiu LL, Xiang L, Gao JJ, Zhang XF, Cui SX. Protective effects of Salvia plebeia compound homoplantaginin on hepatocyte injury. Food Chem Toxicol. 2009, 47:1710-1715.
Zhang X, Zhong JL, Liu W, Gao Z, Xue X, Yue P, Wang L, Zhao C, Xu W, Qu X. N(3)-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU. Cancer Chemother Pharmacol 2010; 66(1):11-9.
Cui SX, Qu XJ, Gao ZH, Zhang YS, Zhang XF, Zhao CR, Xu WF, Li QB, Han JX. Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells. Cancer Lett. 2010, 292: 153-162.
Gao JJ, Gao ZH, Zhao CR, Yuan Y, Cui SX, Zhang XF, Cheng YN, Xu WF, Tang W, Qu XJ. LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin. Invest New Drugs. 2011, 29: 574-582.
Li-Rui Sun, Julia Li Zhong, Shu-Xiang Cui, Xun Li, S.G. Ward, Yan-Qiu Shi, Xiao-Fan Zhang, Yan-Na Cheng, Jian-Jun Gao, Xian-Jun Qu: Modulation of P-glycoprotein activity by substituted quinoxalinones compound QA3 in adriamycin-resistant K562/A02 cells. Pharmacological Reports, 2010; 62: 333-342.
Zhao CR, Gao ZH, Qu XJ. Nrf2-ARE signaling pathway and natural products for cancer chemoprevention. Cancer Epidemiol. 2010, 34: 523-533.
Xue X, Qu XJ, Gao ZH, Sun CC, Liu HP, Zhao CR, Cheng YN, Lou HX. Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II. Invest New Drugs. 2012: 30:212–222.
Pan Yue, Zu-Hua Gao, Xia Xue, Shu-Xiang Cui, Cui-Rong Zhao, Yi Yuan, Zhe Yin, Yoshinori Inagaki, Norihiro Kokudo, Wei Tang, Xian-Jun Qu. Des-γ-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signaling pathway. Eur J Cancer. 2011; 47: 1115-1124.
Xiao-dan Wang, Zu-hua Gao, Xia Xue, Yan-na Cheng, Pan Yue, Xu-wen Fang, Xian-jun Qu. N1-acetyl substituted pyrrolidine derivative CIP-A5: A novel compound that could ameliorate liver cirrhosis through modulation of hepatic stellate cell activity. Toxicol In Vitro. 2011, 25: 897-904.
Hui-Ping Liu, Zu-Hua Gao, Shu-Xiang Cui, Xia Xue, Chun-Ying Hou, Zhi-Mei Jiang, Cui-Rong Zhao, Chun-Bo Wang, Shou-Guo Chen, Xian-Jun Qu. Haishengsu, a protein from shellfish Tegillarca L. granosa, inhibits the growth and the activity of matrix metalloproteinases-2 and -9 in human lung carcinoma. Food Biophys. 2011, 6: 390-396.
Gao JJ, Xue X, Gao ZH, Cui SX, Cheng YN, Xu WF, Tang W, Qu XJ. LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo. Microvasc Res. 2011; 82: 122-30.
Sun CC, Zhang YS, Xue X, Cheng YN, Liu HP, Zhao CR, Lou HX, Qu XJ. Inhibition of angiogenesis involves in anticancer activity of riccardin D, a macrocyclic bisbibenzyl, in human lung carcinoma. Eur J Pharmacol. 2011; 667: 136-143.
Yuan C, Zhang YS, Cheng YN, Xue X, Xu WF, Qu XJ: A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene. Leuk Lymphoma. 2012;53:295-304.
Xue X, Sun DF, Sun CC, Liu HP, Yue B, Zhao CR, Lou HX, Qu XJ. Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: in vitro and in vivo studies. Lung Cancer. 2012. 76 300-308.
Sun DF, Gao ZH, Liu HP, Yuan Y, Qu XJ. Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RAR expression. Cancer Lett. 2012, 319: 182-189.
Hui-Ping Liu, Zu-Hua Gao, Shu-Xiang Cui, De-Fu Sun, Yan Wang, Cui-Rong Zhao, Hong-Xiang Lou, Xian-Jun Qu: Inhibition of intestinal adenoma formation in APCMin/+ mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsute. Plos. One. 2012, 7(3): e33243.
Zhao C, Yue B, Liu H, Sun C, Li W, Qu X. SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine. Toxicol Appl Pharmacol. 2012;262(3):293-300.
Zhao C, Xue X, Li G, Sun C, Sun C, Qu X, Li W. Synthesis and Biological Evaluation of Oral Prodrugs Based on the Structure of Gemcitabine. Chem Biol Drug Des. 2012; 80(3) :479-88.
Yue B, Zhang YS, Xu HM, Zhao CR, Li YY, Qin YZ, Wang RQ, Sun D, Yuan Y, Lou HX, Qu XJ. Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human hepatocellular carcinoma growth through induction of apoptosis in p53-dependent way. Cancer Lett. 2013; 328 104-113.
Yue B, Zhao CR, Xu HM, Li YY, Cheng YN, Ke HN, Yuan Y, Wang RQ, Shi YQ, Lou HX, Qu XJ. Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human oral squamous carcinoma cells KB and KB/VCR: In vitro and in vivo studies. Biochimica et Biophysica Acta (BBA) - General Subjects 2013; 1830; 2194-2203.
Liu HP, Gao ZH, Cui SX, Wang Y, Li BY, Lou HX, Qu XJ. Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellicacid (AKBA) in APC(Min/+) mice. Int J Cancer. 2012 Nov 7. doi: 10.1002/ijc.27929. [Epub ahead of print]
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