课程名称/讲座主题（中文）

Enzymes in Drug   Discovery

酶学在药物开发中的应用

授课/讲座人姓名

Prof. Yujun   George Zheng

授课/讲座对象

药学院研究生

课程/讲座主题描述

Enzymes are one of the most attractive targets for   small molecule drug discovery in disease therapy. The attractiveness of   enzymes as targets stems from their essential catalytic roles in many   physiological processes that may be altered in disease states. The structural   determinants of enzyme catalysis lend themselves well to inhibition by small   molecular weight, drug-like molecules. This short course serves as a   state-of-the-art training of graduate students with knowledge, experience,   and skills in learning and understanding enzyme biochemistry, enzyme   inhibitor screening and design, mode of action analysis, and many important   subjects in enzyme targeting in present pharmaceutical industry.

课程/讲座日程安排

日期

上课/讲座时间

地点

课时数

授课/讲座内容

开始时间

下课时间

7.16

3:00pm

5:00pm

7104

2

Enzymes and Receptors

7.17

10:00am

12:00am

7104

2

Enzyme steady state kinetics   (1)

7.18

10:00am

12:00am

7104

2

Enzyme steady state kinetics   (2)

7.19

3:00pm

5:00pm

7104

2

Enzyme transient state   kinetics

7.20

3:00

5:00

7104

2

pH isotope effects in enzyme   catalysis

7.21

3:00

5:00

7104

2

Enzyme assays and drug   screening

7.22

3:00

5:00

7104

2

Kinetics of reversible enzyme inhibitors   (1)

7.23

3:00

5:00

7104

2

Kinetics of reversible enzyme inhibitors   (2)

7.24

10:00am

12:00am

7104

2

Irreversible and tight binding   enzyme inhibitors

7.25

3:00

5:00

7104

2

Novel enzyme targets in drug   discovery (1)

7.26

3:00

5:00

7104

2

Novel enzyme targets in drug   discovery (2)