基本情况

李慧，博士，山东大学药学院副研究员，药剂学专业，山东大学青年学者未来计划入选人。研究方向主要围绕功能性小分子药物的体内空间控制开展，利用新型功能化药物递释系统探索肿瘤与炎症性疾病的多效免疫联合治疗研究以及新型制剂起效过程中病灶部位内环境与免疫微环境的相互作用研究等。作为项目负责人承担“博士后国际交流计划”引进项目资助（YJ20180129），资助金额60万元（全国299人/年，药学学科5人）；山东省自然科学基金青年项目（ZR2021QH024），资助金额15万元。目前，以第一作者/共同一作或通讯作者发表研究性论文3篇、综述性论文1篇（Advanced Healthcare Materials；ACS Biomaterials Science & Engineering；ACS Applied Materials & Interfaces；pharmaceutics），以第二作者参与发表研究性论文3篇、综述性论文1篇（Angewandte Chemie International Edition*2；Advanced Healthcare Materials；药学进展）；参与发表研究性论文4篇（Haematologica；Giant；Nutrients;Drug Delivery）；以第二位发明人申请国家发明专利3项、其中授权1项，第三位发明人申请国家发明专利4项、其中授权3项；入围全国博士后创新创业大赛总决赛并获得团队优胜奖（5/8）。

通讯地址：山东省济南市文化西路44号，山东大学药学院

电话：（86）13864189649

Email:lihui0476@sdu.edu.cn

研究领域

•功能性小分子药物的体内空间控制

•新型药物载体材料的设计与构建

•药物递送系统用于抗肿瘤与炎症性疾病的多效免疫联合治疗

教育经历

•2013-10至2018-05,比利时根特大学,药剂学,博士

•2010-09至2013-07,山东中医药大学,中药学,硕士

•2005-09至2009-07,山东大学,药学,学士

工作经历

•2019-01至2022-07,博士后国际交流计划”引进项目,特别资助类博士后，山东大学

•2022-07至今，副研究员，药学院，山东大学

项目/奖励

•山东省自然科学基金-青年基金项目，山东省自然科学基金委员会.

•“博士后国际交流计划”引进项目，人力资源和社会保障部&全国博士后管理委员会.

•第一届全国博士后创新创业大赛-优胜奖(团队成员)，中华人民共和国人力资源和社会保障部.

•2015年比利时根特大学药学院国际学术会议奖学金.

•2014年比利时根特大学CSC-co-funding联合奖学金.

•2013年国家建设高水平大学公派研究生项目.

发表论文/专利

发表论文：

1.Yutong Liu*;Hui Li*;Huajun Zhao; Yanyun Hao; Simon Van Herck; Zejun Xu; Guan Wang; Xiao Wang; Xinke Zhang; Xiaoyan Ge; Xia Li; Ailu Yang; Hongfei Chen; Jing Zou; Wentao Wang; Bruno G De Geest*; Zhiyue Zhang*; In Situ Tumor Vaccination with Calcium-linked Degradable Coacervate Nanocomplex Co-delivering Photosensitizer and TLR7/8 agonist to Trigger Effective Anti-tumor Immune Responses,Advanced Healthcare Materials, 2022，202102781.

2.Lingling Huang; Xiaoyan Ge; Yang Liu;Hui Li *; Zhiyue Zhang *; The role of Toll-like receptor agonists and their nanomedicines for tumor immunotherapy,pharmaceutics, 2022, 14061228.

3.Hui Li; Simon Van Herck; Yongjun Liu; Yanyun Hao; Xiaochu Ding; Lutz Nuhn; Zifu Zhong; Francis Combes; Niek N. Sanders; Stefan Lienenklaus; Stefaan D. Koker; Sunil A. David; Yadong Wang; Bruno G De Geest*; Zhiyue Zhang*; Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy,ACS Biomaterials Science & Engineering, 2020, 6(9): 4993-5000.

4.Hui Li;Kaat Fierens; Zhiyue Zhang; Nane Vanparijs, et al.; Bruno G. De Geest*; Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery.ACS applied materials & interfaces, 2016. 8(2): p. 1147-1155.

5.Yanyun Hao;Hui Li; Xiaoyan Ge; Yang Liu; Xia Li; Yutong Liu; Hongfei Chen; Shiying Zhang; Lingling Huang; Fabao Zhao; Dongwei Kang; Bruno G De Geest; Zhiyue Zhang*; Tumor-Selective Activation of Toll-Like Receptor 7/8 Agonist Nano-Immunomodulator Generates Safe Anti-Tumor Immune Responses upon Systemic Administration,Advanced Healthcare Materials, 2022, 202214992.

6.Yanyun Hao;Hui Li;Huajun Zhao; Yutong Liu; Xiaoyan Ge; Xia Li; Hongfei Chen; Ailu Yang; Jing Zou; Xue Li; Xuechun Sun; Xinke Zhang; Xiao Wang; Zepeng Li; Qilu Zhang; Hao Wu; Guan Wang; Jian Zhang; Bruno G De Geest*; Zhiyue Zhang*; An Intelligent Nano-vehicle Armed with Multi-functional Navigation for Precise Delivery of Toll-like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity,Advanced Healthcare Materials, 2022, 202102739R1.

7.李霞;李慧;张志岳*;刺激响应型聚合物在肿瘤免疫治疗方面的研究进展,药学进展, 2021, 45(5): 325-326

8.Zhiyue Zhang;Hui Li; Sabah Kasmi; Simon Van Herck; Kim Deswarte; Bart N. Lambrecht; Richard Hoogenboom; Lutz Nuhn; Bruno G. De Geest*; A Synthetic Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window,Angewandte Chemie International Edition, 2019, 58: 7866 (IF：15.336)

9.Wenhao Hao; Huali Meng;Hui Li; Chunhong Song; Xue Bai; Zhiyue Zhang; Lei Du; Pei Liu; Hao Wu*; Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice,Nutrients,2022, 14(19), 4139.

10.Zepeng Li; Kannan Senthil; Yawei Sun; Yi Wang; Haohui Huo; Yanyun Hao; Yutong Liu; Hongfei Chen;Hui Li;Zhiyue Zhang; Goran Ungar; Qilu Zhang*; Feng Liu*; Nearly monodisperse unimolecular micelles via chloro-based atom transfer radical polymerization, Giant, 2021, 7(100062).

11.Xin Li; Zi Sheng; Yuanxin Sun; Yuanjian Wang; Miao Xu; Zhiyue Zhang;Hui Li;Linlin Shao; Yanqi Zhang; Jinming Yu; Chunhong Ma; Chengjiang Gao; Ming Hou; Heyu Ni; Jun Peng; Ji Ma*; Qi Feng*; Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia, Haematologica, 2020, 106.

12.Zhiyue Zhang, Xiuli Bi,Hui Li,Guihua Huang*. Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration. Drug Delivery, 2011, 18(7)：536-544.