基本情况:
彭明,博士,山东大学药学院副研究员,硕士研究生导师,天然药物化学专业,山东大学青年学者未来计划入选者。主要从事微生物活性次级代谢产物生物合成及药物和靶标的结构生物学研究,以生物信息学、结构生物学、分子生物学、生物化学等为主要研究手段,对活性次级代谢产物生物合成途径关键酶的三维结构以及合成关键步骤的分子机制进行研究。作为项目负责人主持国家自然科学基金青年基金项目、山东省自然科学基金青年基金项目、中国博士后科学基金面上项目等国家级和省部级课题。以(共同)第一/通讯作者的研究成果相继发表在Nature Microbiology、Nature Communications、Applied and Environmental Microbiology等国际主流期刊。
通讯地址:山东省济南市文化西路44号,山东大学药学院
电话:(+86)18353118213
Email:pengm@sdu.edu.cn
研究方向:
1. 活性次级代谢产物生物合成关键酶的挖掘、三维结构及分子机制解析
2. 药物和靶标的结构生物学
学习及工作经历:
2022.8-至今 山东大学药学院 副研究员
2020.7-2022.7 山东大学微生物技术国家重点实验室博士后
2015.9-2020.6 山东大学微生物技术国家重点实验室博士
主持/参与课题:
1. 国家自然科学基金青年基金项目,42106142,2022.1.1-2023.12.31 ,主持
2. 山东省自然科学基金青年基金项目,ZR2021QD071,2022.1.1至2024.12.31,主持
3. 中国博士后科学基金面上项目,2021M691914,2021.7.1-2023.6.30,主持
4. 青岛市博士后研究人员应用项目资助,62450071311033,2021.1.1-2022.12.31,主持
5. 微生物技术国家重点实验室开放课题面上项目,M2023-19,2023.7.1-2025.6.30,主持
6. 山东大学青年学者未来计划项目,2023.1.1-2027.12.31,主持
7. 山东大学药学院基本科研业务费资助项目,2022.1.1-2024.12.31,主持
8. 国家自然科学基金重大研究计划项目, 91851205,2019.1.1-2022.12.31,参与
9. 国家自然科学基金重大研究计划项目,91751101,2018.1.1-2020.12.31,参与
10. 国家自然科学基金面上项目,32070109,2020.1.1-2022.12.31,参与
11. 国家自然科学基金面上项目,31670038,2017.1.1-2020.12.31,参与
代表性学术论文:
1. Peng M#, Li CY#, Chen XL, Williams BT, Li K, Gao YN, Wang P, Wang N, Gao C, Zhang S,Schoelmerich MC, Banfield JF, Miller JB, Le Brun NE, Todd JD*, Zhang YZ* Insights into methionineS-methylation in diverse organisms. Nature Communications. 2022, 13:2947. Doi : 10.1038/s41467-022-30491-5.
2. Carrión O#*, Li CY#*,Peng M# (co-first author), Wang JY, Pohnert G, Azizah M, Zhu XY, Curson AR.J., Wang Q, Walsham KS, Zhang XH, Monaco S, Harvey JM, Chen XL, Gao C, Wang N, Wang XJ, Wang P, Giovanonni SJ, Lee CP, Suffridge CP, Zhang Y, Luo ZQ, Wang DZ, Todd JD*, Zhang YZ* Function and wide distribution of DMSOP cleaving enzymes in marine organisms. 2023.Nature Microbiology (principle to publish).
3. Peng M, Chen XL, Zhang D, Wang XJ, Wang N, Wang P, Todd JD, Zhang YZ, Li CY*. Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.Applied and Environmental Microbiology. 2019 Apr 4;85(8). pii: e03127-18. Doi: 10.1128/AEM.03127-18.
4. Yang J, Zhong S, Chen XL, Yu Y, Zhang YZ, Su HN, Song XY, Peng M*. A Direct Circular Dichroic Assay for Quantitative Determination of Peptide Enantiomers. Acta Biochemica et BiophysicaSinica. 2021 Oct 12; 53(10). 1412-1415. Doi: 10.1093/abbs/gmab104.
5. Chen XL#,Peng M#(co-first author), Li J#, Tang BL, Shao X, Zhao F, Liu C, Zhang XY, Li PY, Shi M, Zhang YZ, Song XY*. Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913.Scientific Reports. 2017 Nov 16;7(1):15716.Doi: 10.1038/s41598-017-15971-9.
6. Wang Y#, Wang P#, Cao HY, Ding HT, Su HN, Liu SC, Liu GF, Zhang X, Li CY,Peng M, Li FC, Li SY, Chen Y, Chen XL*, Zhang YZ*; Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis,Nature Communications, 2022, 13(1):566. doi: 10.1038/s41467-022-28264-1.
7. Williams BT, Cowles K, Bermejo Martínez A, Curson ARJ, Zheng Y, Liu J, Newton-Payne S, Hind AJ, Li CY, Rivera PPL, Carrión O, Liu J, Spurgin LG, Brearley CA, Mackenzie BW, Pinchbeck BJ,Peng M, Pratscher J, Zhang XH, Zhang YZ, Murrell JC, Todd JD. Bacteria are important dimethylsulfoniopropionate producers in coastal sediments.Nature Microbiology. 2019 Nov;4(11):1815-1825. doi: 10.1038/s41564-019-0527-1.
8. Shao X, Cao HY, Zhao F,Peng M, Wang P, Li CY, Shi WL, Wei TD, Yuan Z, Zhang XH, Chen XL, Todd JD, Zhang YZ*. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria.Molecular Microbiology. 2019 Apr;111(4):1057-1073. doi: 10.1111/mmi.14211.
9. Li CY, Chen XL, Zhang D, Wang P, Sheng Q, Peng M, Xie BB, Qin QL, Li PY, Zhang XY, Su HN, Song XY, Shi M, Zhou BC, Xun LY, Chen Y, Zhang YZ. Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.Molecular Microbiology. 2017 Mar;103(6):992-1003.Doi: 10.1111/mmi.13605.
10. Wang N, Chen XL, Gao C, Peng M, Wang P, Zhang N, Li FC, Yang GP, Shen QT, Li SY, Chen Y, Zhang YZ, Li CY*. Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine. Journal of Biological Chemistry. 2020 Nov 21; 296:100081. Doi: 10.1074/jbc.RA120.015952.
11.Li DD,Peng M, Wang N, Wang XJ, Zhang XY, Chen XL, Su HN, Zhang YZ, Shi M*.Arcticibacterium luteifluviistationis gen. nov., sp. nov., isolated from Arctic seawater.International Journal of Systematic and Evolutionary Microbiology 2017 Apr;67(3):664-669.Doi: 10.1099/ijsem.0.001690.
12. Li DD, Zhang YQ,Peng M, Wang N, Wang XJ, Zhang XY, Li PY, Xie BB, Chen XL, Zhang YZ, Qin QL*. Erythrobacter xanthus sp. nov., isolated from surface seawater of the South China Sea.International Journal of Systematic and Evolutionary Microbiology. 2017 Jul;67(7):2459-2464. doi: 10.1099/ijsem.0.001991.
13.Cao HY, Wang P,Peng M, Shao X, Chen XL, Li CY*. Crystal structure of the dimethylsulfide monooxygenase DmoA from Hyphomicrobium sulfonivorans.Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):781-786. doi: 10.1107/S2053230X18015844.
14.Li DD, Liu C, Zhang YQ, Wang XJ, Wang N,Peng M, Song XY, Su HN, Zhang XY, Zhang YZ, Shi M. Flavobacterium arcticum sp. nov., isolated from Arctic seawater.International Journal of Systematic and Evolutionary Microbiology. 2017 Apr;67(4):1070-1074. doi: 10.1099/ijsem.0.001804.
主要奖励及荣誉:
1. 国家奖学金(2019)
2. 山东大学优秀学术成果奖(2020)
3. 山东大学优秀毕业生(2020)
4. 山东大学“海右”博士学术论坛主讲人(2020)