一、基本情况
李翔，男，博士，山东济南人，山东大学药学院副教授，药物化学专业硕士生导师，2020年入选山东大学青年学者未来计划。主要研究领域为基于模式生物的人类疾病模型构建、药物筛选方法开发研究及应用。主持国家自然科学基金、山东省自然科学基金等多个项目。以第一作者或通讯作者发表论文20余篇。
通讯地址:山东省济南市历下区文化西路44号山东大学趵突泉校区
Email:lixiang@sdu.edu.cn
二、学习及工作经历
2017.7-至今 山东大学，药学院，助理研究员、副教授
2022.12-2023.12 国家留学基金委公派（CSC）访问学者
2014.9-2017.6 南开大学，博士
2011.9-2014.6 南开大学，硕士
2007.9-2011.7 山东第一医科大学（山东省医学科学院），学士
三、研究领域
1.基于模式生物斑马鱼的人类疾病模型构建
2.基于模式生物斑马鱼的药物筛选和药物发现
3.基于模式生物斑马鱼的药物高通量筛选技术开发
4.基于模式生物斑马鱼的化合物毒性效应及机制研究
5.模式动物行为学表型组学方法学开发及在药物筛选中的应用
四、教学工作
本科生课程《医药研究中的模式生物》
五、承担课题
2020.8-2025.8 山东大学青年学者未来计划,在研
2020.1-2022.12 国家自然科学基金青年项目（21906095），已结题
2019.7-2022.6 山东省自然科学基金（ZR2019BB018），已结题
2018.11-2019.12 中国博士后科学基金面上资助一等资助，已结题
2017.9-2019.12 山东大学基本业务费，已结题
六、代表性文章
1. Ning Yan; Fei Xie; Long-Qian Tang; De-Feng Wang;Xiang Li *; Chao Liu*and Zhao-Peng Liu*. Synthesis and biological evaluation of thieno [3,2-c] pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease,Bioorganic Chemistry,138 (2023) 106663.
2. Xiang Liand Minyong Li*.The application of zebrafish patient-derived xenograft tumor models on the development of anti-tumor agents,Medicinal Research Reviews,2023; 43: 212- 236.
3. Xiang Li#,Gaopan Dong#, Guangxi Han, Lupei Du, Mingyong Li*. Zebrafish Behavioral Phenomics Links Artificial Sweetener Aspartame to Behavioral Toxicity and Neurotransmitter Homeostasis,Journal of agricultural and food chemistry, 2021, 69, 50, 15393-15402.
4. Guangxi Han#,Xiang Li#, Gaopan Dong, Ling Zhang, Jianxiang Gao, Minyong Li, and Lupei Du*.Phenotyping Aquatic Neurotoxicity Induced by the Artificial Sweetener Saccharin at Sublethal Concentration Levels.Journal of Agricultural and Food Chemistry.2021,69, 7, 2041–2050.
5. Xiang Li, Jiao Dang, Yan Li, Lizhen Wang,Ning Li, Kechun Liu, Meng Jin*.Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method.Science of The Total Environment.2021Jan 15; 752:141878.
6. Xiang Li, Xiuna Ji, Rongchun Wang, Jinghang Zhao, Jiao Dang, Yan Gao, Meng Jin*.Zebrafish behavioral phenomics employed for characterizing behavioral neurotoxicity caused by silica nanoparticles.Chemosphere,2020. 240: 124937.
7. Gaopan Dong#,Xiang Li#, Guangxi Han, Lupei Du, Minyong Li*.Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of “no observed effect concentrations (NOECs)”.Chemosphere,2020. 243: 125431.
8. Xiang Li, Baoyue Zhang,Ning Li, Xiuna Ji, Kechun Liu*, Meng Jin*.Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level.Chemosphere,2019, 231: 315-325.
9. Xiang Li, Haotian Kong, Xiuna Ji, Yan Gao, Meng Jin*.Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level.Chemosphere,2019, 224: 445-454.
10. Xiang Li#,Yuan Zhang#, Xu Li#, Daofu Feng#, Shuhui Zhang, Xin Zhao, Donyan Chen*, Zhixiang Zhang*, Xizeng Feng*.Comparative analysis of biological effect of corannulene and graphene on developmental and sleep/wake profile of zebrafish larvae.Acta Biomaterialia.2017, 55: 271-282.
