理学博士，教授，博士生导师。山东大学药学院药物智能制造技术研究团队。
国家药品监督管理局器审中心外聘专家、国家药品监督管理局药物制剂研究与评价重点实验室骨干成员、山东省企业科技特派员。
国家自然科学基金评审专家，ACS Nano、J Controlled Release等杂志审稿专家。
研究方向为开发基于缓控释体系的药用原料、辅料及连续化生产工艺，推动缓控释药物制剂生产的产业化发展。
近年来，先后主持国家自然科学基金、山东省自然科学基金研究项目、山东省重点研发计划项目等科研课题10余项，参与国家重点研发计划、山东省自然科学基金重大基础研究等项目研究。发表高水平科研论文40篇。获得国家发明专利10项。研究成果曾获山东省教育厅高校学校科学技术一等奖。
教育经历：
(1) 2001-09至2006-06，浙江大学，物理化学，博士。
(2) 1997-09至2001-06，曲阜师范大学，化学教育，学士。
科研与学术工作经历：
(1) 2006.7-2013.12山东大学药学院讲师
(2) 2009.5-2011.12山东大学药学院天然药物化学研究所博士后
(3) 2013.1-2014.1美国北卡罗来纳大学教堂山分校访问学者
(4) 2014.1-2023.8山东大学药学院博士生导师，副教授
(5) 2023.9-至今山东大学药学院博士生导师，教授
承担课题
(1)mRNA脂质纳米递送系统的精准构筑及肺部靶向机制研究，2024-2027，国家自然科学基金面上项目，项目负责人。
(2)纳米制剂在肿瘤微环境复杂转运体系中的跨血管内皮细胞热力学机制研究（ZR2023MB082），2024-2026，山东省自然科学基金面上项目，项目负责人。
(3)基于热力学的主动靶向纳米药物在肿瘤微环境中的靶向机制研究（ZR2019MB041），2019-2022，山东省自然科学基金面上项目，项目负责人。
(4)基于热力学的主动靶向纳米药物在肿瘤微环境中的靶向机制研究（21873057），2019-2022，国家自然科学基金面上项目，项目负责人。
(5)基于肿瘤微环境的主动靶向纳米药物的靶向机制研究，2018-2020，山东大学交叉学科研究项目，项目负责人。
(6)基于新型医用高分子聚合物材料的BMP-2载药微球的可控制备技术及工艺研究（2017GGX202007），2017-2018，山东省重点研发计划，项目负责人
(7)具有肿瘤靶向的多西他赛pH敏感脂质体的可控制备及敏感机制研究（21203112），2013-2015，国家自然科学基金（青年基金），项目负责人
(8)面向中药方剂四逆汤配伍关系的生物热动力学分析理论与实验研究（ZR2012BQ002），2012-2014，山东省自然科学基金（青年基金），项目负责人
(9)微量热技术用于四逆汤配伍规律的研究（201003069），2010-2012，山东省博士后创新基金，项目负责人
(10)中草药耐药性及其生物活性的生物热动力学研究(2007BS02002)，2007至2010，山东省中青年科学家奖励基金项目，项目负责人
(11)中草药抗菌能力生物热力学评价理论及实验研究，2011至2013，山东大学自主创新基金自然科学专项，项目负责人
发表论文
1.Fu, M., Qiu, S., Wang, F.,Lin, G., Shi, Y., Qin, Z., Tang, B., Li, X., Zhang, J. (2023). Enhanced Osteogenic Properties of Bone Repair Scaffolds through Synergistic Effects of Mechanical and Biochemical Stimulation. Advanced Engineering Materials, 25 (13).
2.Wang, W., Shi, Y.,Lin, G., Tang, B., Li, X., Zhang, J., Ding, X., Zhou, G. (2023). Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair. Macromolecular Bioscience, 23 (7).
3.Zhou, G., Wang, F.,Lin, G., Tang, B., Li, X., Ding, X., Wang, W., Zhang, J., Shi, Y. (2023). Novel coatings for the continuous repair of human bone defects. Colloids and Surfaces B: Biointerfaces, 222. 113127
4.Wu, Y., Wang, F., Shi, Y.,Lin, G., Qiao, J., Wang, L. (2022).Molecular dynamics simulation of hyaluronic acid hydrogels: Effect of water content on mechanical and tribological properties.Computer Methods and Programs in Biomedicine, 226,107169.
5.Fu, X., Shi, Ye microenvironment. Journal of controlled release : official journal of the Controlled Rele., Zang, H., Wang, Q., Wang, Y., Wu, H., Qiu, S., Shen, H., Mo, F., Zhang, Y., &Lin, G.(2022). Combination of oxaliplatin and POM-1 by nanoliposomes to reprogram the tumor immun ase Society, 347, 1–13.
6.Zhang, Y., Tang, B., Xin, Y., Wu, Q., Liu, L., Wang, Y., Zhu, K.,Lin, G.,& Wang, H. (2022). Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection.Journal of Zhejiang University. Science. B,23(9), 778–783.
7.Wu, Y., Li, X., Wang, Y., Shi, Y., Wang, F.,Lin, G.(2022).Research progress on mechanical properties and wear resistance of cartilage repair hydrogel.Materials and Design,216,110575, .
8.Liu, H., Wang, L.,Lin, G., Feng, Y. (2022). Recent progress in the fabrication of flexible materials for wearable sensors.Biomaterials Science,10 (3). 614-632.
9.Fu, M., Wang, F., &Lin, G. (2021). Design and research of bone repair scaffold based on two-way fluid-structure interaction. Computer methods and programs in biomedicine, 204, 106055.
10.Zhou, S., Li, J., Yu, J., Wang, Y., Liu, H.,Lin, G., He, Z., & Wang, Y. (2021). Unique flower-like Cur-metal complexes loaded liposomes for primary and metastatic breast cancer therapy. Materials science & engineering. C, Materials for biological applications, 121, 111835.
11.Zhou, S., Li, J., Yu, J., Yang, L., Kuang, X., Wang, Z., Wang, Y., Liu, H.,Lin, G., He, Z., Liu, D., & Wang, Y. (2021). A facile and universal method to achieve liposomal remote loading of non-ionizable drugs with outstanding safety profiles and therapeutic effect. Acta pharmaceutica Sinica. B, 11(1), 258–270.
12.Jiang, B., Gao, Y., Shi, Y., Qi, T., Qiu, S.,Lin, G., Feng, Y. (2021). Numerical simulation analysis and structural optimization design of microspheres prepared by a high-pressure homogenizer.Separation and Purification Technology, 277, 119374, .
13.Fu, X., Shi, Y., Qi, T., Qiu, S., Huang, Y., Zhao, X., Sun, Q., &Lin, G*. (2020). Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting. Signal transduction and targeted therapy, 5(1), 262.
14.Yu J, Wang Y, Zhou S, Li J, Wang J, Chi D, Wang X,Lin G, He Z, Wang Y. Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy. Acta Pharm Sin B. 2020 Sep;10(9):1730-1740.
15.Wang, Z., Lin, X., Chi, D., Xu, Z.,Lin, G., Liu, H., Sun, J., He, Z., & Wang, Y. (2020). Single-ligand dual-targeting irinotecan liposomes: Control of targeting ligand display by pH-responsive PEG-shedding strategy to enhance tumor-specific therapy and attenuate toxicity. International journal of pharmaceutics, 587, 119680.
16.Kong, D., Shi, Y., Gao, Y., Fu, M., Kong, S., &Lin, G. (2020). Preparation of BMP-2 loaded MPEG-PCL microspheres and evaluation of their bone repair properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 130, 110516.
17.Gao, Y., Shi, Y., Fu, M., Feng, Y.,Lin, G., Kong, D., & Jiang, B. (2020). Simulation study of the effects of interstitial fluid pressure and blood flow velocity on transvascular transport of nanoparticles in tumor microenvironment. Computer methods and programs in biomedicine, 193, 105493.
18.Yan, W.,Lin, G., Zhang, R., Liang, Z., & Wu, W. (2020). Studies on the bioactivities and molecular mechanism of antioxidant peptides by 3D-QSAR, in vitro evaluation and molecular dynamic simulations. Food & function, 11(4), 3043–3052.
19.Fu, X., Shi, Y., Wang, H., Zhao, X., Sun, Q., Huang, Y., Qi, T., &Lin, G*. (2019). Ethosomal Gel for Improving Transdermal Delivery of Thymosin β-4. International journal of nanomedicine, 14, 9275–9284.
20.Huang, Y., Shi, Y., Wang, Q., Qi, T., Fu, X., Gu, Z., Zhang, Y., Zhai, G., Zhao, X., Sun, Q., &Lin, G*. (2019). Enzyme responsiveness enhances the specificity and effectiveness of nanoparticles for the treatment of B16F10 melanoma. Journal of controlled release : official journal of the Controlled Release Society, 316, 208–222.
21.Gao, Y., Shi, Y., Wang, L., Kong, S., Du, J.,Lin, G., & Feng, Y. (2020). Advances in mathematical models of the active targeting of tumor cells by functional nanoparticles. Computer methods and programs in biomedicine, 184, 105106
22.Huang, Y., Gu, Z., Fan, Y., Zhai, G., Zhao, X., Sun, Q., Shi, Y., &Lin, G*. (2019). Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future. Purinergic signalling, 15(1), 53–67.
23.Liu, M., Khan, A. R., Ji, J.,Lin, G., Zhao, X., & Zhai, G. (2018). Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses. Journal of controlled release : official journal of the Controlled Release Society, 290, 150–164.
24.Gu, Z., Wang, Q., Shi, Y., Huang, Y., Zhang, J., Zhang, X., &Lin, G*. (2018). Nanotechnology-mediated immunochemotherapy combined with docetaxel and PD-L1 antibody increase therapeutic effects and decrease systemic toxicity. Journal of controlled release : official journal of the Controlled Release Society, 286, 369–380.
25.Gu, Z., Shaikh, A. S., &Lin, G*. (2018). Novel 'Stereoscopic Response' Strategy Can Be Used in Combination Therapy. Critical reviews in therapeutic drug carrier systems, 35(4), 369–390.
26.Gu, Z., Chang, M., Fan, Y., Shi, Y., &Lin, G*. (2017). NGR-modified pH-sensitive liposomes for controlled release and tumor target delivery of docetaxel. Colloids and surfaces. B, Biointerfaces, 160, 395–405.
27.Fan, Y., Wang, Q.,Lin, G*., Shi, Y., Gu, Z., & Ding, T. (2017). Combination of using prodrug-modified cationic liposome nanocomplexes and a potentiating strategy via targeted co-delivery of gemcitabine and docetaxel for CD44-overexpressed triple negative breast cancer therapy. Acta biomaterialia, 62, 257–272.
28.Han, X., Chen, J., Jiang, M., Zhang, N., Na, K., Luo, C., Zhang, R., Sun, M.,Lin, G., Zhang, R., Ma, Y., Liu, D., & Wang, Y. (2016). Paclitaxel-Paclitaxel Prodrug Nanoassembly as a Versatile Nanoplatform for Combinational Cancer Therapy. ACS applied materials & interfaces, 8(49), 33506–33513.
29.Fan, Y., Chen, C., Huang, Y., Zhang, F., &Lin, G*. (2017). Study of the pH-sensitive mechanism of tumor-targeting liposomes. Colloids and surfaces. B, Biointerfaces, 151, 19–25.
30.Zuo, T., Guan, Y., Chang, M., Zhang, F., Lu, S., Wei, T., Shao, W., &Lin, G*. (2016).RGD(Arg-Gly-Asp) internalized docetaxel-loaded pH sensitive liposomes: Preparation, characterization and antitumor efficacy in vivo and in vitro. Colloids and surfaces. B, Biointerfaces, 147, 90–99.
31.Chang, M., Zhang, F., Wei, T., Zuo, T., Guan, Y.,Lin, G*., & Shao, W. (2016). Smart linkers in polymer-drug conjugates for tumor-targeted delivery. Journal of drug targeting, 24(6), 475–491.
32.Zhang, F., Zhang, Y., Wang, K., Zhu, X.,Lin, G., Zhao, Z., Li, S., Cai, J., & Cao, J. (2015). Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice. International immunopharmacology, 29(2), 326–333.
33.Zhang, F., Chang, M., Yu, Y., Zhang, Y.,Liu, G*., Wei, T., Zuo, T., Guan, Y., Lin, G., & Zhao, Z. (2015). Preparation and evaluation of lipid emulsified docetaxel-loaded nanoparticles. The Journal of pharmacy and pharmacology, 67(11), 1546–1555.
34.Shi, Y. B., Liu, L., Shao, W., Wei, T., &Lin, G*. M. (2015). Microcalorimetry studies of the antimicrobial actions of Aconitum alkaloids. Journal of Zhejiang University. Science. B, 16(8), 690–695.
35.Guan, Y., Zuo, T., Chang, M., Zhang, F., Wei, T., Shao, W., &Lin, G*. (2015). Propranolol hydrochloride-loaded liposomal gel for transdermal delivery: Characterization and in vivo evaluation. International journal of pharmaceutics, 487(1-2), 135–141.
36.Chang, M., Lu, S., Zhang, F., Zuo, T., Guan, Y., Wei, T., Shao, W., &Lin, G*. (2015). RGD-modified pH-sensitive liposomes for docetaxel tumor targeting. Colloids and surfaces. B, Biointerfaces, 129, 175–182.
37.Lin, G*., Zhang, H., & Huang, L. (2015). Smart polymeric nanoparticles for cancer gene delivery. Molecular pharmaceutics, 12(2), 314–321.
38.Zhang, H., Wang, K.,Lin, G*., & Zhao, Z. (2014). Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy. BMC complementary and alternative medicine, 14, 270.
39.Zhang, H., Li, R. Y., Lu, X., Mou, Z. Z., &Lin, G*. M. (2012). Docetaxel-loaded liposomes: preparation, pH sensitivity, pharmacokinetics, and tissue distribution. Journal of Zhejiang University. Science. B, 13(12), 981–989.
40.Lin, G. M., Liu, L., & Shao, W. (2011). Microcalorimetry studies on the antibacterial effect of crude monkshood polysaccharide. Journal of Zhejiang University. Science. B, 12(7), 563–567.
获得的国家发明专利
1.王庆杰，黄艺，林贵梅.一种紫杉醇与多肽共递送系统、制备方法及应用，2022.3.18, ZL201910726966.6,已授权.
2.林贵梅，邱胜男，傅相蕾.一种负载帕瑞昔布、白介素-4和牛血清白蛋白用于骨关节炎治疗的双层微球及其制备方法，2022.3.25，ZL202111482061.2，已授权.
3.林贵梅，傅相蕾，邱胜男，一种内质网膜融合脂质体及其制备方法和应用，2022.07.26，ZL 202111419857.3，已授权。
4.林贵梅，张艳坤，傅相蕾，邱胜男。一种超声、荧光双重显影负载量子点纳米泡及其制备方法和应用，2022.04.28，ZL 202210460523.9，已授权
5.林贵梅，张艳坤。负载紫杉醇脂质体的泊洛沙姆温敏凝胶及制备方法与应用，2022.03.31，ZL 202210332216.2，已授权
6.林贵梅，傅相蕾，王慧.一种胸腺素β-4醇质体及其制备工艺，2021.3.2，ZL201810951630.5，已授权.
7.郭红梅，祁同同，林贵梅.共载CD73抗体和阿霉素的脂质体及其制备方法和应用，2021.12.28，ZL202111000301.0，已授权.
8.王庆杰，古自力.一种用于免疫化疗的pH敏感脂质体，2020.5.18, ZL201810602566.X,已授权.
9.林贵梅，宋燕媚，俸小仟，李玥，史岩彬.一种BMP-2/PPLA微球及其制备方法，2020.10.2，ZL201710056118.X，已授权.
10.林贵梅，管圆圆，邵伟，卢杉杉，左甜甜，常明露。盐酸普洛萘尔脂质凝胶及其制备方法，2016.01.20，ZL201310647695.8，已授权
获得的科技奖励
山东省高校科学技术一等奖，（2019），pH敏感脂质体的可控制备及敏感机制研究
