一、基本情况
张志岳，博士，山东大学药学院教授，药剂学专业博士生导师，泰山学者青年专家，山东省优青。2017年入选“山东大学齐鲁青年学者”，截止目前，已在Angewandte Chemie International Edition（3篇），Journal of Controlled Release, Advanced Functional Materials（3篇），Advanced Healthcare Materials（2篇）等著名综合性期刊或药剂学领域顶级学术期刊发表SCI论文40余篇。现为中国药学会高级会员，国家公派出国留学评审专家。
通讯地址：山东省济南市文化西路44号，山东大学齐鲁医学院药学院
电子邮箱：zhiyue.zhang@sdu.edu.cn
二、研究领域
方向1：基于多功能聚合物的合成、修饰制备新型药物传递载体。
方向2：靶向修饰纳米粒作为药物传递系统的研究。
方向3：药物递送系统用于抗肿瘤免疫联合治疗
三、工作及学习经历
2018.10 -至今， 山东大学药学院，教授、博士生导师
2016.10-2018.09，比利时根特大学（Ghent University, Belgium），博士后研究员
2012.10-2016.05，比利时根特大学（Ghent University, Belgium），博士
2009.09-2012.06，山东大学，硕士
2005.09-2009.06，山东大学，学士
四、承担课题
1、国家自然科学基金委员会国际(地区)合作与交流项目/课题
2、国家自然科学基金面上项目
3、国家自然科学基金委员会与欧盟委员会“中欧人才项目”
4、国家自然科学基金青年项目
5、山东省自然科学基金优秀青年基金项目
6、山东省自然科学基金青年项目
7、教育部“春晖计划”合作研究项目
8、国家药品监督管理局药物制剂技术研究与评价重点实验室开放课题
9、山东大学“齐鲁青年学者”科研启动基金；
10、中澳健康科学研究中心联合基金
五、代表性学术论文（限10篇，*通讯作者）
1.Zhang Z, Li H, Kasmi S, Van Herck S, Deswarte K, Lambrecht BN, Hoogenboom R, Nuhn L, De Geest BG. A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window.Angew Chem Int Ed.2019Jun 3;58(23):7866-7872.
2.Hao Y, Li H, Ge X, Liu Y, Li X, Liu Y, Chen H, Zhang S, Zou J, Huang L, Zhao F, Kang D, De Geest BG,Zhang Z*. Tumor-Selective Activation of Toll-Like Receptor 7/8 Agonist Nano-Immunomodulator Generates Safe Anti-Tumor Immune Responses upon Systemic Administration.Angew Chem Int Ed. 2022Dec 23;61(52):e202214992.
3.Liu Y, Li H, Zhao H, Hao Y, Van Herck S, Xu Z, Wang G, Wang X, Zhang X, Ge X, Li X, Yang A, Chen H, Zou J, Wang W, De Geest BG*,Zhang Z*. In Situ Tumor Vaccination with Calcium-Linked Degradable Coacervate Nanocomplex Co-Delivering Photosensitizer and TLR7/8 Agonist to Trigger Effective Anti-Tumor Immune Responses.Adv Healthc Mater. 2022Jun;11(12):e2102781.
4.Hao Y, Li H, Zhao H, Liu Y, Ge X, Li X, Chen H, Yang A, Zou J, Li X, Sun X, Zhang X, Wang X, Li Z, Zhang Q, Wu H, Wang G, Zhang J, De Geest BG*,Zhang Z*. An Intelligent Nanovehicle Armed with Multifunctional Navigation for Precise Delivery of Toll-Like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity.Adv Healthc Mater. 2022Jun;11(12):e2102739.
5.Ge X, Hao Y, Li H, Zhao H, Liu Y, Liu Y, Li X, Chen H, Zou J, Zhang S, Huang L, Shan G,Zhang Z*. Sequential acid/reduction response of triblock copolymeric nanomicelles to release camptothecin and toll-like receptor 7/8 agonist for orchestrated chemoimmunotherapy.J Nanobiotechnology. 2022Aug 11;20(1):369.
6.Hao Y, Li H, Ge X, Liu Y, Yin J, Li X, Liu Y, Chen H, Huang L, Zou J, Zhang S, Wu H,Zhang Z*. Site-specific nanoswitch circumventing immune resistance via activating TLR and inhibiting PD-L1/PD-1 axis.J Control Release. 2023Sep;361:64-76.
7.Yanyun Hao, Hui Li, Fangfang Ren, Ruihua Feng, Yang Liu, Xia Li, Hongfei Chen, Jing Zou, Lingling Huang, Shiying Zhang, Gang Shan, Zhijie Yang*,Zhiyue Zhang*.Ferrocene-conjugated polymeric platform via amide bond formation facilitates enhanced in situ fenton reaction and robust immune responses in combination with toll-like receptor 7/8 agonist.Chemical Engineering Journal, 2023,472, 144909.
8. Liu Y, Li H, Hao YY, Huang LL, Li X, Zou J, Zhang SY, Yang XY, Chen HF, Guo YX, Guan YY,Zhang ZY*. Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors.Small. 2024Oct 10:e2406870.
9. Xuelian Zhang, Hang Li, Yang Liu, Jie Yu, Pengfei Zhang, Peiling Yu, Yuhao Liu, Suyi Jia, Lijuan Ling, Peng Li, Lei Li, Yueyao Wang, Tengxiao Huang, Gaoxin Jin, Yunpeng Zhao, Guoli Ma, Qinghao Yuan, Lei Zhu,Zhiyue Zhang*, Hao Li*, Weiwei Li*, Acid-responsive CST@NPs enhanced diabetic wound healing through rescuing mitochondrial dysfunction,Bioactive Materials, 2025,44, 269-282.
10. Ruinan Jia1, Yang Liu1, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye,Zhiyue Zhang*, Tao Sun*, Chunyan Ji*. A ROS-Responsive Dual-Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T-Cell Acute Lymphoblastic Leukemia.Adv Sci. 2025May 31:e05087.
