一.基本情况
李孝训,博士,山东大学药学院教授,药物化学专业博士生导师。2017年入选“山东大学齐鲁青年学者”。近五年,已在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、ACS Catal.、Chem. Sci.等国际著名刊物上发表论文二十余篇。
通讯地址:山东省济南市文化路44号,山东大学药学院
Email:xli@sdu.edu.cn
二.学习及工作经历
2017.12 –至今 山东大学药学院,教授,博士生导师
2015.03 – 2017.06 美国斯坦福大学,博士后;
2009.07 – 2014.12 美国威斯康星大学麦迪逊分校,博士;
2007.09 – 2009.07 天津大学,硕士;
2003.09 – 2007.07 天津大学,本科;
三.研究方向
1.基于靶点结构的药物活性小分子的设计、合成及生物活性研究;
2.具有重要生理活性的复杂天然产物的全合成及构效关系研究;
3.高效构建手性杂环小分子的新方法及新策略研究。
四.承担课题
1.国家自然科学基金青年项目(21901142),2020.01-2022.12,主持
2.山东省自然科学基金青年项目(ZR2019QB001),2019.07-2022.06,主持
3.山东大学“齐鲁青年学者”启动基金,2017.12-2022.12,主持
4.山东大学青年交叉科学创新群体,2020.01-2023.12,子课题负责人
五.代表性学术论文(限10篇)
1. Jianhua Wang,Xiaoxun Li*. Asymmetric β-Arylation of Cyclopropanols Enabled by Photoredox and Nickel Dual Catalysis.Chem. Sci.2022, DOI: 10.1039/D1SC07237D.
2. Mingjun Lv,Xiaoxun Li*. Ni(II)-Catalyzed Asymmetric Nitration of Oxindoles: Construction of Cipargamin Analogues.ACS Catal.2021,11, 14829-14835.
3. Can Gao, Xunhua Wang, Jitian Liu*,Xiaoxun Li* Highly Diastereo- and Enantioselective Synthesis of Tetrahydrobenzo[b]azocines via Palladium-Catalyzed [4 + 4] Cycloaddition.ACS Catal.2021,11, 2684-2690.
4. Jianhua Wang, Stephanie A. Blaszczyk,Xiaoxun Li*, Weiping Tang* Transition Metal-Catalyzed Selective Carbon−Carbon Bond Cleavage of Vinylcyclopropanes in Cycloaddition Reactions.Chem. Rev.2021,121, 110-139.
5. Kai Liu, Jianfeng Yang,Xiaoxun Li*Palladium-Catalyzed Diastereo- and Enantioselective [3 + 2] Cycloaddition of Vinylcyclopropanes with Azadienes: Efficient Access to Chiral Spirocycles.Org. Lett.2021,23, 826-831.
6. Jitian Liu,* Wenjing Ye, Shuojin Wang, Junrong Zheng, Weiping Tang,Xiaoxun Li*Synthesis of Lactams via Ir-Catalyzed C−H Amidation Involving Ir- Nitrene Intermediates.J. Org. Chem.2020,85, 4430-4440.
7. Barry M. Trost*,Xiaoxun Li. Palladium Catalyzed Asymmetric Allylic Alkylations via C-H Activation of N-allyl Imines and Glycinates.Chem. Sci.2017,8, 6815-6821.
8.Xiaoxun Li, Hui Li, Wangze Song, Po-Sen Tseng, Lingyan Liu,*Ilia A. Guzei, Weiping Tang* Divergent Reactivity of Rhodium (I) Carbenes Derived from Indole Annulations.Angew. Chem. Int. Ed.2015,54, 12905-12908.
9.Xiaoxun Li, Wangze Song, Weiping Tang* Rhodium-catalyzed Tandem Annulation and [5+1] Cycloaddition: 3-Hydroxy -1,4-enyne as the 5-Carbon component.J. Am. Chem. Soc.2013,135, 16797-16800.
10.Xiaoxun Li, Min Zhang, Dongxu Shu,Patrick J. Robichaux, Suyu Huang, Weiping Tang* Rhodium-catalyzed Ring Expansion of Cyclopropanes to Seven-membered Rings by 1,5-C-C Bond Migratio.Angew. Chem. Int. Ed.2011,50, 10421-10424.