个人信息

单刚，男，博士，山东大学药学院教授，药物化学专业博士生导师。2019年入选山东省泰山学者青年专家项目和山东大学齐鲁青年学者项目。

教育背景与工作经历

2019.06 – 至今 山东大学药学院， 药物化学专业， 教授、博士生导师

2018.04 – 2019.04 哈佛大学医学院丹娜法伯癌症研究所，博士后

2015.09 – 2018.04 德国马普分子生理学研究所，博士后

2010.09 – 2015.07 清华大学药学院，博士

2006.09 – 2010.07 山东大学药学院，学士

研究方向

1. 开发新型的靶向光敏剂用于肿瘤的光动力治疗和蛋白组学研究；

2. 开发新型的生物正交反应用于可激活前药设计。

近五年代表性论文

1. Jingru Qiu, Qinghong Liu, Baolan Chen, Zhongfei Gao, Shuo Zhang, Yayin Du, Donghai Li^*, Guiling Li^*, and Gang Shan^*, STAT3 Pathway Targeting Type I Photosensitizer as an Immune Stimulator for Cancer Photoimmunotherapy, Journal of Medicinal Chemistry, 2025, 68(15), 16103-16113.

2. Shuo Zhang, Jingru Qiu, Hao Zhang, Baolan Chen, Xinke Zhang, Donghai Li^*, Guiling Li^*, Gang Shan^*, Pyrazolo[1,5-a]pyrimidine-Based Type-I Photosensitizer as an Efficient Pyroptosis Inducer for Tumor Ablation, Journal of Medicinal Chemistry, 2025, 68(10), 10048-10060.

3. Weijia Chen^#, Jingru Qiu^#, Peixia Li, Qianqian Zhang, Donghai Li, Guiling Li^*, Gang Shan^*, Simultaneous Induction of Immunogenic Pyroptosis and PD-L1 Downregulation by One Single Photosensitizer for Synergistic Cancer Photoimmunotherapy, Journal of Medicinal Chemistry, 2025, 68 (3), 3612-3625.

4. Peixia Li, Yayin D, Jingru Qiu, Qiaoyun Jiang, Weijia Chen, Xinke Zhang, Guiling Li^*, Donghai Li^*, Gang Shan^*, Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy, Journal of Medicinal Chemistry, 2024, 67 (21), 18930-18942.

5. Peixia Li, Yayin Du, Jingru Qiu, Donghai Li, Guiling Li^*, Gang Shan^*, Nuclear PARP1‐Targeted Photosensitizer as A Dual‐Mode DNA‐Damaging Agent and Immune Activator for Tumor Ablation, Advanced Healthcare Materials, 2023, 12 (31), 2301517.

6. Jingru Qiu, Qinghong Liu, Peixia Li, Qiaoyun Jiang, Weijia Chen, Donghai Li, Guiling Li^*, Gang Shan^*, Ligand-Directed Photodegradation of Interacting Proteins: Oxidative HER2/HER3 Heterodimer Degradation with a Lapatinib-Derived Photosensitizer, Journal of Medicinal Chemistry, 2023, 66 (15), 10265-10272.

7. Jiang Qiaoyun^#, Li Peixia^#, Jingru Qiu, Donghai Li, Guiling Li^*, Gang Shan^*, Lysosome-Targeting Phenalenones as Efficient Type I/II Photosensitizers for Anticancer Photodynamic Therapy, European Journal of Medicinal Chemistry, 2023, 255, 115418.

8. Guiling Li^#, Peixia Li^#, Qiaoyun Jiang, Qianqian Zhang, Jingru Qiu, Donghai Li^*, Gang Shan^*, Discovery of a pyridophenoselenazinium-based photosensitizer with high photodynamic efficacy against breast cancer cells，Acta Materia Medica, 2023, 2 (1), 96-105.

9. Yanyun Hao, Hui Li, Fangfang Ren, Ruihua Feng, Yang Liu, Xia Li, Hongfei Chen, Jing Zou, Lingling Huang, Shiying Zhang, Gang Shan, Zhijie Yang, Zhiyue Zhang, Ferrocene-Conjugated Polymeric Platform via Amide Bond Formation Facilitates Enhanced in Situ Fenton Reaction and Robust Immune Responses in Combination with Toll-like Receptor 7/8 Agonist，Chemical Engineering Journal, 2023, 472, 14490.

10. Xiaoyan Ge, Yanyun Hao, Hui Li, Huajun Zhao, Yang Liu, Yutong Liu, Xia Li, Hongfei Chen, Jing Zou, Shiying Zhang, Lingling Huang, Gang Shan, Zhiyue Zhang, Sequential Acid/Reduction Response of Triblock Copolymeric Nanomicelles to Release Camptothecin and Toll-like Receptor 7/8 Agonist for Orchestrated Chemoimmunotherapy, Journal of Nanobiotechnology, 2022, 20, 369.