一、基本情况
杨斐，博士，副研究员，硕士生导师。近年来以第一作者或通讯作者身份在Angew. Chem. Int. Ed.,Adv. Mater.,Bioact. Mater.,APSB,Chem. Eng. J.,Small,J. Hazard. Mater.,Biosens. Bioelectron.等国际著名学术期刊上发表SCI论文30余篇。以核心发明人（排名前三）身份申请国家发明专利17件，迄今已获授权11件。主持国家自然科学基金、山东省重点扶持区域引进急需紧缺人才项目、山东省重点研发计划、山东省自然科学基金、广东省基础与应用基础研究基金、中国博士后科学基金等项目8项；作为主要成员参与国家重点研发计划、国家自然科学基金、山东省重点研发计划、山东省自然科学基金等项目7项。获山东省科技进步奖二等奖2项、稀土科学技术奖二等奖1项、山东化学化工学会自然科学奖一等奖1项。
地址：山东省济南市文化西路44号山东大学药学院
E-mail：yangfei@sdu.edu.cn
二、研究领域
智能水凝胶的设计合成与生物医学应用
纳米药物、纳米生物材料的设计与可控制备
纳米酶的设计构建及在生物医学领域的应用
三、工作及学习经历
2022.6 - 至今 山东大学，药学院，副研究员
2019.1 - 2022.3 山东大学，药学院，博士后（特别资助类）
2016.9 - 2018.3 美国匹兹堡大学，联合培养（国家公派）
2013.9 - 2018.12 山东大学，有机化学专业，获理学博士学位
2009.9 - 2013.6 山东大学，应用化学专业，获理学学士学位
四、教学工作
理论课程：无机化学（必修）
实验课程：无机化学实验（必修）、有机化学实验（必修）
五、承担课题
1. 国家自然科学基金青年基金，水凝胶介导的原位CAR-M编程在骨肉瘤术后协同治疗与修复中的机制研究，2027-01至2029-12，30万元，主持
2. 山东省重点扶持区域引进急需紧缺人才项目计划，高端宠物用驱虫药氟雷拉纳关键技术研究及产业化，2025-04至2026-03，100万元，主持
3. 山东省重点研发计划，二丙酸咪唑苯脲原料药和注射剂的开发及产业化应用，2024-09至2026-08，20万元，主持
4. 山东省自然科学基金青年基金，纳米粒子表面配体的制备、修饰及催化反应的研究，2022-01至2024-12，15万元，主持
5. 广东省基础与应用基础研究区域联合基金-青年基金，新型有机-无机纳米复合材料的设计、合成与应用研究，2023-11至2026-10，10万元，主持
6. 中国博士后科学基金特别资助（站前），树枝状配体分子包覆无机纳米颗粒的自组装及性质研究，2019-06至2021-06，18万元，主持
7. 横向项目，高端兽用（宠物用）原料药及制剂技术开发，2025-11至2028-12，100万元，主持
8. 横向项目，胆碱的工艺优化及氨基酸硝酸盐的研发，2023-10至2026-11，30万元，主持
六、代表性论文
1.Fei Yang, Xinyong Liu, and Zhijie Yang*. Chiral Metal Nanoparticle Superlattices Enabled by Porphyrin-Based Supramolecular Structures.Angew. Chem. Int. Ed.,2021,60, 14671-14678.
2. Chunwei Tang, Kun Han, Xin Wen, Jing Zhang, Weiyi Sun, Xiao Yue, Lihui Shi, Zejuan Liu, Jianxiong Zhao, Chongzheng Yan, Miaoyan Liu, Zichao Yao, Zhichao Kong, Ying Liu, Zhipeng Fu, Xiaotian Zhao, Zhenmei Yang, Maosen Han, Chen Chen, Zhaoquan Xing*, Xiaoming Zhou*,Fei Yang*, Yulin Zhang*, Xinyi Jiang*. Synthetic Disaggregators Enhance Central-Peripheral Amyloid-β Clearance in Alzheimer's Disease.Adv. Mater.,2026,38, e20002.
3. Junyuan Sun#,Fei Yang#（共一）, Lianlei Wang#, Haichao Yu#, Zhijie Yang, Jingjing Wei, Krasimir Vasilev, Xuesong Zhang*, Xinyu Liu*, Yunpeng Zhao*. Delivery of Coenzyme Q10 Loaded Micelle Targets Mitochondrial ROS and Enhances Efficiency of Mesenchymal Stem CellTherapy in Intervertebral Disc Degeneration.Bioact. Mater.,2023,23, 247-260.
4. Chongdeng Shi#, Maosen Han#, Hui Yang#, Xiaotian Zhao, Zuolin Zheng, Huijun Wang, Zhipeng Fu, Kuan Dai, Kun Zhao, Na Li, Yudong Song*, Chen Chen*, Anning Li*,Fei Yang*, Xinyi Jiang*. In situ Generation of EBNA1 CAR-T cells Eradicates Antigen Specific Auto-immune B Cells for Multiple Sclerosis Treatment.APSB,2026,16, 4676-4691.
5. Fenghua Zhang#,Fei Yang#（共一）, Yanjun Gong, Yanze Wei, Yanzhao Yang, Jingjing Wei*, Zhijie Yang* and Marie-Paule Pileni. Anisotropic Assembly of Nanocrystal/Molecular Hierarchical Superlattices Decoding from Tris-Amide Triarylamines Supramolecular Networks.Small,2020,16, 2005701.
6. Zhexu Gai, Yeping Liu, Peng Liu, Chuanwei Shi, Shang Sun, Yanzhao Yang,Fei Yang*. CuS@PDA-Fe3+Nanozymes Orchestrate NIR-Enhanced Enzyme Cascades for Synergistic Antibacterial Therapy.Chem. Eng. J.,2026,533, 174693.
7. Yeping Liu, Zhexu Gai, Chuanwei Shi, Peng Liu, Yanzhao Yang,Fei Yang*. Composite Nanoarchitectonics of Nanozymes with Cascade Enzyme Activity Enable Controlled Regulation of Reactive Oxygen Species for Bacterial Infection-Induced Wound Healing.ACS Appl. Mater. Interfaces.,2026,18, 20291-20303.
8.Fei Yang, Jingjing Wei*, Wei Liu, Jinxin Guo* and Yanzhao Yang. Copper Doped Ceria Nanospheres: Surface Defects Promoted Catalytic Activity and a Versatile Approach.J. Mater. Chem. A,2014,2, 5662-5667.
9. Peng Liu, Qiaoyu Li, Yifan Chen, Xiaowei Yue,Fei Yang*, Yanzhao Yang*. Synergistic Antibacterial Platform Based on Chitosan-Modified MnO2Nanozyme-Loaded Lactobacillus Rhamnosus for Wound Infection Management.Chem. Eng. J.,2026,537, 176316.
10. Peng Liu, Chuanwei Shi, Yeping Liu,Fei Yang*, Yanzhao Yang*. Multifunctional Nanozyme Capsule for Sensitive Bacterial Detection and Synergistic Antibacterial Therapy.Chem. Eng. J.,2025,516, 164260.
11. Xiaojun Guo,Fei Yang*, Lu Jing, Jie Li, Yanhong Li, Rui Ding, Binqiu Duan, Xiaomei Zhang*. In-Situ Generation of Highly Active and Four-in-One CoFe2O4/H2PPOP Nanozyme: Mechanism and Its Application for Fast Colorimetric Detection of Cr (VI).J. Hazard. Mater.,2022,431, 128621.
12. Xiaowei Yue, Peng Liu, Yifan Chen, Linqing Du,Fei Yang*, Yanzhao Yang*. Visual Detection of Uric Acid and Antibacterial Applications in Gout Wound Healing Based on His@Fe-SHMP Nanozyme.Biosens. Bioelectron.,2026,312, 118988.
13.Peng Liu, Chuanwei Shi, Yeping Liu,Fei Yang*, Yanzhao Yang*. Development of AI-Integrated Smartphone Sponge-Based Sensors Utilizing His@Co-NC Nanozymes for Highly Sensitive Sarcosine Detection.Biosens. Bioelectron.,2025,286, 117621.
14.Fei Yang, Guiming Ba, Zhen Wang, and Haiping Li*. Surface Modification Induced Construction of Core-Shell Homojunction of Polymeric Carbon Nitride for Boosted Photocatalytic Performance.J. Colloid Interface Sci.,2021,594, 64-72.
15. Guangbin Ji,Fei Yang*, Yanzhao Yang, Jingjing Wei and Zhijie Yang*.Dynamic Emulsion Droplets Enabled by Interfacial Assembly of Azobenzene-Functionalized Nanoparticles under Light and Magnetic Field.J. Colloid Interface Sci.,2021,583, 586-593.
16. Peng Liu, Yeping Liu, Zhexu Gai,Fei Yang*, Yanzhao Yang*. Highly Specific Colorimetric Detection of Sarcosine Using Surface Molecular Imprinted Zn/Ce-ZIF.J. Colloid Interface Sci.,2025,681, 239-249.
17. Chuanwei Shi, Peng Liu, Yeping Liu, Zhexu Gai,Fei Yang*, Yanzhao Yang*. Accelerating Chronic Wound Healing by Breaking the pH Limitations of Biomolecule-Loaded Nanozymes and Remodeling the Microenvironment in Cascade Reactions.J. Colloid Interface Sci.,2025,700, 138370.
18. Zhexu Gai, Yeping Liu, Peng Liu, Jun Li, Chuanwei Shi, Ronghao Liu,Fei Yang*, Yanzhao Yang*. Dual-Mechanism Driven Type-II FeS2/Co3S4Heterointerface Nanozymes Overcoming Near-Physiological pH Constraints for Precision Xanthine Biosensing.ACS Appl. Mater. Interfaces,2025,17, 44228-44239.
19. Peng Liu, Linqing Du, Fang Luan, Chuanwei Shi, Yeping Liu, Zhexu Gai,Fei Yang* and Yanzhao Yang*. Multifunctional Nanozyme with Aptamer-Based Ratiometric Fluorescent and Colorimetric Dual Detection of Prostate-Specific Antigen.ACS Appl. Mater. Interfaces,2025,17, 7553-7567.
20. Peng Liu, Jun Li, Zhen Wang, Xiaowei Yue,Fei Yang*, Jinxin Guo*, Yanzhao Yang*. AI-Enhanced Ratiometric Dual-Fluorescence Paper Sensor for Ethanol Detection in Alcoholic Beverages.Sensors Actuat. B-Chem.,2026,446, 138640.
21. Huijuan Zhao, Tingting Liu, Lin Cui*, Yanhong Li,Fei Yang*, Xiaomei Zhang*. Label-Free and Dual-Amplified Electrochemical Bioanalysis of MUC1 Based on an Inorganic-Organic Polymer Hybrid Mimic Peroxidase (AuNPs@Cu7S4@Cu/Mn-AzoPPOP) and Catalytic Hairpin Assembly.Sensors Actuat. B-Chem.,2021,345, 130332.
22. Peng Liu, Qian Sun, Zhexu Gai,Fei Yang*, Yanzhao Yang*. Dual-Mode Fluorescence and Colorimetric Smartphone-Based Sensing Platform with Oxidation-Induced Self-Assembled Nanoflowers for Sarcosine Detection.Anal. Chim. Acta,2024,1306, 342586.
23. Huijuan Zhao, Tingting Liu,Fei Yang*. Photoelectrochemical Polarity-Switching-Mode and Split-Type Biosensor Based on SQ-COFs/BiOBr Heterostructure for the Detection of Uracil-DNA Glycosylase.Talanta,2023,262, 124694.
24. Peng Liu, Chuanwei Shi, Yeping Liu, Zhexu Gai, Hao Tian,Fei Yang*, Yanzhao Yang*. Triple-Signal Strategy Utilizing a Colorimetric, Fluorescence, and Chromogenic Paper-Based Sensor for Rapid Detection of ATP at Neutral pH.Talanta,2025,292, 127976.
25. Yeping Liu,Fei Yang*, Peng Liu, Congcong Lou, Liqin Zhu, Yanzhao Yang*. CeO2-Coated Porphyrin-Based Porous Organic Polymers as Nanozymes for Efficient Antimicrobial Activity.ACS Appl. Nano Mater.,2024, 7, 23076-23086.
26.Congcong Lou, Liqin Zhu,Fei Yang*.NH2-MIL-88B@TP-TA@CuS for Photothermal Catalytic Synergistic Antibacterial Activity. Colloid Surface B,2024,242, 114094.
27. Liqin Zhu, Congcong Lou, Xiaomei Zhang,Fei Yang*. Hg2+‑Enhanced Oxidase‑Like Activity of Platinum Nanoparticles Immobilized on Porphyrin‑Based Porous Organic Polymer for the Colorimetric Detection and Removal of Hg2+.Microchim. Acta,2024, 191, 378.
28. Liqin Zhu,Fei Yang*, Congcong Lou, Xiaomei Zhang, Yanzhao Yang*. Hollow Porphyrin-Based Porous Organic Polymer with Dual Enzyme-Like Activities for Ultra-Fast Colorimetric Detection of Cr (VI) in Wastewater.Microchim. Acta,2023, 190, 339.
29. Congcong Lou,Fei Yang*, Liqin Zhu, Qian Sun, Yanzhao Yang, Jinxin Guo*. Dual-Function Sensor Based on NH2-MIL-101(Fe)@Cu/CeO2Nanozyme for Colorimetric and Fluorescence Detection of Heavy Metals.Colloid Surface A,2023, 677, 132398.
30.Fei Yang, Yangshan Li, Paul E. Floreancig*, Xiaoyan Li* and Lei Liu*.Copper-Catalyzed Oxidative Cross-Dehydrogenative Coupling of 2H-Chromenes and Terminal Alkynes.Org. Biomol. Chem.,2018,16, 5144-5149.
31.Fei Yang,Yangyang Wang, Faguan Lu, Shangqing Xie, Xinghao Qi, Hongjian Sun, Xiaoyan Li*, Olaf Fuhr and Dieter Fenske.Preparation of Hydrido [CNC]-Pincer Cobalt Complexes via Selective C-H/C-F Bond Activation and Their Catalytic Performances.New J. Chem.,2018,42, 15578-15586.
32.Fei Yang, Yongkai Deng, Lingyu Guo, Haifeng Su, Zvonko Jagličić*, Zhenyu Feng, Guilin Zhuang*, Suyuan Zeng and Di Sun*. Structural, Electrochemical and Magnetic Analyses of a New Octanuclear MnIII2MnII6Cluster with Linked-Defect Cubane Topology.CrystEngComm,2016,18, 1329-1336.
33.Fei Yang, Lu Jing, Lisha Ji, Qingyun Liu and Xiaomei Zhang*. Design, Fabrication and the Relative Catalytic Properties of Metal-Organic Framework Complexes Based on Tetra(4-carboxyphenyl)porphyrin and Cerium Ions.CrystEngComm,2014,16, 4274-4280.
七、授权专利
1. 一种具有抗菌功能的纳米酶及其制备方法与应用，ZL202410134620.8
2. 一种中空卟啉基多孔有机聚合物及其制备方法与在比色检测Cr（Ⅵ）中的应用，ZL202211541086.X
3. 一种检测重金属的纳米酶及其制备方法及应用，ZL202211615363.7
4. 一种负载铂纳米粒子的多孔有机材料的制备及其在比色检测和去除Hg2+中的应用，ZL202410125914.4
5. 一种用于分离铑的萃取剂、及其制备、萃取方法，ZL202310606064.5
6. 一种高离子密度的聚离子液体吸附剂及其制备和回收铂(IV)的方法，ZL202311569266.3
7. 一种分离金属钯的浸取剂及其制备与浸取方法，ZL202310252262.6
8. 一种以水玻璃为硅源制备二氧化硅酚醛树脂复合气凝胶材料的方法，ZL202011640147.9
9. 一种萃取分离钕（Ⅲ）的萃取剂及其制备方法与应用，ZL202210354862.9
10. 一种温控型贵金属分离萃取剂及其制备方法与均相萃取方法，ZL202111486373.0
11. 一种用于废电子电器回收的浸取剂、制备方法及银浸取回收方法，ZL202311415184.3
八、所获主要奖励及荣誉
山东省科技进步奖二等奖（2项）
稀土科学技术奖二等奖
山东化学化工学会自然科学奖一等奖
研究生国家奖学金
山东大学优秀研究生
山东大学优秀学生干部
优秀共产党员
“晨曦杯”研究生学术论文杰出奖
主持国家级大学生创新创业训练计划立项项目，研究成果获校级一等奖
主持第五届大学生科研作品立项校级重点项目，研究成果获校级一等奖
