一、基本信息
刘代喜，女，博士，现任山东大学药学院助理研究员、硕士研究生导师。主要从事新型抗感染及抗肿瘤活性天然产物的发现及功能研究工作。
邮箱：liudaixi@sdu.edu.cn
二、教育及工作经历
2022.12-至今， 山东大学药学院，助理研究员
2020.7-2022.11，山东大学海洋研究院，博士后
2016.09-2020.7，山东大学海洋研究院，海洋生物学，博士
三、研究方向
1）海洋蓝细菌来源的活性次级代谢产物挖掘及其生物合成途径研究；
2）药用动物来源的活性毒素多肽的发现及功能研究。
四、代表性论文
(1) Liu Daixi#; Lv Haibo#; Wang Yafei#; Chen Jinyu; Li Dexin; Huang Ranran*; Selective RNA processing and stabilization are multi-layer and stoichiometric regulators of gene expression in Escherichia coli, Advanced Science, 2023, 2301459.
(2) Liu Daixi, Chen Bokun, Meng Yue, Wang Yafei, Zhao Wei, Ji Hongli, Yang Xue, Zhu Minghao, Zheng Li, Li Gang, Liu Jihua. Silicon uptake via the transporters SySIT-L and SyLsi-L enhances the growth and photosynthesis of Synechococcus sp. PCC 7002. mBio. 2025 Aug 25:e0184425.
(3) Wang Yafei, Meng Yue, Ren Hongwei, Huang Ranran, Liu Jihua, Daixi Liu*; Synechococcus sp. PCC 7002 performs anoxygenic photosynthesis and deploys divergent strategies to cope with H2Sn and H2O2, Antioxidants 2025, 14, no. 9: 1122.
(4) Liu Daixi; Chen Jinyu; Wang Yafei; Meng Yue; Li Yuanning; Huang Ranran; Xia Yongzhen; Liu Huaiwei; Jiao Nianzhi; Xun Luying; Liu Jihua*; Synechococcus sp. PCC7002 uses Peroxiredoxin to cope with reactive sulfur species stress, mBio, 2022, 13(4).
(5) Liu Daixi; Zhang Jiajie; Lü Chuanjuan; Xia Yongzhen; Liu Huaiwei; Jiao Nianzhi; Xun Luying; Liu Jihua*; Synechococcus sp. strain PCC7002 uses sulfide:quinone oxidoreductase to detoxify exogenous sulfide and to convert endogenous sulfide to cellular sulfane sulfur, mBio, 2020, 11(1).
(6) Liu Daixi; Song Hui; Li Yuanning; Huang Ranran; Liu Hongyue; Tang Kunxian; Jiao Nianzhi; Liu Jihua*; The transcriptional repressor PerR senses sulfane sulfur by Cysteine persulfidation at the structural Zn2+ site in Synechococcus sp. PCC7002, Antioxidants, 2023, 12(2) (423).
(7) Liu Daixi#; Wang Yuwei#; Wei Lin; Ye Huahu; Liu Huan; Wang Ling; Liu Rui; Li Dongsheng; Lai Ren*; Snake venom-like waprin from the frog of Ceratophrys calcarata contains antimicrobial function, Gene, 2012, 514(2): 99-104.
(8) Huang Ranran; Wang Yafei; Liu Daixi; Wang Shaoyu; Lv Haibo; Yanzhen*; Long-read metagenomics of marine microbes reveals diversely expressed secondary metabolites, Microbiology Spectrum. 2023 Aug 17;11(4): e0150123.
(9) Jinyu Chen; Daixi Liu; Yafei Wang; Shaoyu Wang; Ranran Huang; Effects of selective RNA processing and stabilization enzymes on carbon sequestration by photosynthesis of Synechococcus sp. PCC7002, Frontiers in Marine Science, 2023, 10(1223060)
(10) Lü Chuanjuan; Xia Yongzhen; Liu Daixi; Zhao Rui; Gao Rui; Liu Honglei*; Xun Luying*; Cupriavidus necator H16 uses favocytochrome c sulfide dehydrogenase to oxidize self-produced and added sulfide, Applied and Environmental Microbiology, 2017, 83(22): e01610-17.
五、承担课题
1. 国家自然科学基金青年项目，3240010992，2025.01-2027.12，30万，主持
2. 山东省自然科学基金青年项目，ZR2022QC044，2023.01-2025.12，15万，主持
3. 中国博士后科学基金面上项目，2021M691913，2021.07-2023.07，8万，主持
4. 国家重点研发计划，2020YFA0607604，2020.10-2025.10，39万，子子课题主持
5. 青岛市应用项目资助，5万，主持
