一、基本情况

鲁春华，博士，天然药物化学专业教授、博士生导师，

通讯地址：山东省济南市文化西路44号山东大学药学院新科研楼

E-mail：ahua0966@sdu.edu.cn

二、学习与工作经历

1994.09～1998.06：云南大学生物系，获学士学位；

1998.09～2004.03：中科院昆明植物研究所，获植物学博士学位；

2004.06～2010.07：厦门大学生物系，讲师，副教授；

2010.07～至今：山东大学药学院，副教授，教授。

三、研究方向

1.活性天然产物研究：生物活性指导下，抗菌、抗肥胖、抗肿瘤活性天然产物的发现、鉴定及其生物活性探究。

2.靶向细菌III型分泌系统抗感染药物的发现和作用机制研究。

四、教学工作

承担本科生《抗生素》、《药学综合大实验》、《天然药物化学实验》和研究生《有机波谱解析》等课程的教学。

五、承担课题

1.国家自然科学基金(22377067), 2024-2027，主持；

2.山东省重点研发计划(2024KJHZ024 )，2024-2026，子课题负责人；

3.山东省自然科学基金(ZR2025MS271)，2026-2028，主持

4.国家自然科学基金(2217070336)，2022-2025，主持；

5.国家自然科学基金(81673317)，2017-2020，主持；

6.国家自然科学基金(81373304)，2014.-2017，主持；

7.国家自然科学基金(30500632)，2006‒2008，主持;

8.山东省自然科学基金(ZR2013HQ04)，2014-2016，主持；

9.. 863目标导向课题(20060102Z1083), 2007‒2009，子课题负责人。

六、代表性论文

1.Jiyuan Yang, Qian Zhang, Baobing Zhao, Xiaochun Zhang,Chunhua Lu*,Yuemao Shen. Mesuaferroic cid H supresses HepG2 cell proliferation by disrupting iron homestasis via transferrin targeting. Bioorganic chemistry,2025, 164, 108929.https://doi.org/10.1016/j.bioorg.2025.108929.

2.Xiaochun Zhang,Chunhua Lu*,Yuemao Shen. A natural thiophene fromEclipta prostrata(L.) combats obesity by enhancing adipocytes thermogenesis in high-fat diet-fed obese mice. BBA - Molecular and Cell Biology of Lipids,2025, 1870, 159644.https://doi.org/10.1016/j.bbalip.2025.159644.

3.Xintong Li, Xiaochun Zhang, Chan Yin,Chunhua Lu*,Yuemao Shen. Design and synthesis ofO-dialkylaminoalkyl substituted urolithin derivatives: DNA topoisomerase IIα inhibition with promising antiproliferative activity. Archiv der Pharmazie,2025, 358: e70009.https://doi.org/10.1002/ardp.70009.

4.Yang Wu, Caixia Zhao,Chunhua Lu*, Yuemao Shen*. Sodium houttuyfonate ameliorates obesity and insulin resistance via UCP1-driven thermogenesis and AKT/GLUT4-mediated glucose metabolism. Food Bioscience,2025, 69, 106999.https://doi.org/10.1016/j.fbio.2025.106999.

5.Zhengzheng Zhang, Luyao Bai,Chunhua Lu*,Xintong Li, Yang Wu, Xiaochun Zhang, Yuemao Shen*. Lapachol inhibits the growth of lung cancer by reversing M2-like macrophage polarization via activating NF-κB signaling pathway. Cellular Signalling 112 (2023) 1109020.https://doi.org/10.1016/j.cellsig.2023.110902.

6.Guangsen Xu, Yuliang Song,Chunhua Lu*, Yuemao Shen*. Synthesis of resveratrol derivatives and their anti-virulence activity as T3SS inhibitors of Salmonella. Journal of Molecular Structure 1276 (2023) 134826.https://doi.org/10.1016/j.molstruc.2022.134826.

7.Rongrong Gao, Zhifang Liu, Xuefei Yang, Yuliang Song, Xiaoyun Cui, Jiyuan Yang,Chunhua Lu*,Yuemao Shen. Specialised metabolites as chemotaxonomic markers ofCoptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae. Phytochemistry,2021, 192: 112929.https://doi.org/10.1016/j.phytochem.2021.112929.

8.Wu Yang, Yang Xuefei, Zhang Dongdong,Lu Chunhua*. Myricanol inhibits the type III secretion systemofSalmonella entericaSerovar Typhimurium by interfering with the DNA-binding activity of HilD. Frontiers In Microbiology.2020, 11:571217.https://doi.org/10.3389/fmicb.2020.571217.

9.Jianxiong Wang, Wen Li, Haoxin Wang,Chunhua Lu*. Pentaketide ansamycin microansamycins A−I fromMicromonosporasp. reveal diverse post-PKS modifications. Organic Letters,2018, 20: 1058−1061.https://doi.org/10.1021/acs.orglett.7b04018.

10.Juanli Zhang, Shanren Li, Xingkang Wu, Zhixing Guo,Chunhua Lu*,Yuemao Shen. Nam7 hydroxylase is responsible for the formation of the naphthalenic ring in the biosynthesis of neoansamycins. Organic Letters,2017,19: 2442−2445.https://doi.org/10.1021/acs.orglett.7b01083.

七、授权专利

1.鲁春华，宋禹良，徐广森，沈月毛；一种真菌聚酮cytosporone B的合成方法；ZL202210209042.0

2.鲁春华，沈月毛，吴杨；杨梅醇在制备抗革兰阴性细菌毒力药物中的应用；ZL201910293960.4

3.鲁春华,沈月毛,李天红；3,4,8,9,10-五羟基二苯骈[b,d]吡喃-6-酮在制备抗菌药物中的应用；ZL201810284124.5

4.沈月毛，鲁春华，张晓春；2.2’:5’,2”-三噻吩-5-羧酸在制备降脂减肥药物中的应用；ZL202310184358.3

5.沈月毛，徐广森，鲁春华；一种2-苯基萘衍生物及其制备方法和应用，ZL 202210921655.7

八、社会兼职

中国化学会会员；Phytochemistry编委会成员；国家级、省部级科技项目评审专家；多家国际著名期刊审稿人。